Practice Contact Information
Tufts Medical Center
800 Washington Street
Web Site: https://www.tuftsmedicalcenter.org/patient-care-services/Departments-and-Services/Ear-Nose-and-Throat-ENT-Otolaryngology/Overview
Areas of Interest in Head and Neck Surgery
Head and Neck Surgeon, Reconstructive Head & Neck Surgery
Dr. Miriam O’Leary is an Assistant Professor of Otolaryngology — Head & Neck Surgery at Tufts Medical Center since 2009. She earned her M.D. at the University of Connecticut. She completed a residency in Otolaryngology — Head & Neck Surgery at Boston University and a fellowship in Head & Neck Oncologic Surgery and Microvascular Reconstruction at the University of Miami. Dr. O’Leary cares for patients with benign and malignant tumors of the head and neck, including the mouth, jaw, throat, voice box, and neck, as well as thyroid, salivary glands, and skin cancers of the head and neck. Dr. O’Leary performs both removal and reconstruction of head and neck tumors. Her research interests include outcomes after head and neck surgery. Dr. O’Leary is the Director of the Multidisciplinary Head & Neck Tumor Board at Tufts Medical Center. She is also an Assistant Clinical Professor of Oral and Maxillofacial Surgery at Tufts Medical Center. Dr. O’Leary is the Residency Program Director of the Otolaryngology — Head & Neck Surgery Residency at Tufts Medical Center.
A Phase 1b/2, Open-Label, Multicentre Study Assessing the Safety, Tolerability, Pharmacokinetics, and Preliminary Anti-tumor Activity of MEDI4736 in Combination With AZD9150 or AZD5069 in Patients With Advanced Solid Malignancies and Subsequently Comparing AZD9150 and AZD5069 Both as Monotherapy and in Combination With MEDI4736 as Second Line Treatment in Patients With Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck
This study is to evaluate the overall response rate of two experimental drugs, AZD9150 and AZD5069, both as single medicine treatments and in combination with another study drug,MEDI4736, in the second-line treatment of patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck.
A Randomized Double-blind Phase 3 Study Of Avelumab In Combination With Standard Of Care Chemoradiotherapy (Cisplatin Plus Definitive Radiation Therapy) Versus Standard Of Care Chemoradiotherapy In The Front-line Treatment Of Patients With Locally Advanced Squamous Cell Carcinoma Of The Head And Neck
This is a phase 3 randomized, placebo controlled study to evaluate the safety and anti-tumor activity of Avelumab in combination with standard of care chemoradiation (SoC CRT) versus SoC CRT alone in front-line treatment of patients with locally advanced head and neck cancer.
A Two-arm, Open-label, Randomized Phase II Study of Pembrolizumab (MK-3475) Monotherapy Versus Standard Chemotherapy in Platinum Pre-treated, Recurrent or Metastatic Nasopharyngeal Cancer (NPC) (Keynote-122)
This is a study of pembrolizumab versus standard of care (SOC) treatment (capecitabine, gemcitabine, or docetaxel) for the treatment of recurrent or metastatic nasopharyngeal cancer (NPC). Participants will be randomly assigned to receive either pembrolizumab or Investigator’s choice of standard treatment.
The primary study hypothesis is that pembrolizumab treatment prolongs progression-free survival (PFS) and overall survival (OS) when compared to SOC treatment.
NRG Oncology NRG-HN001: Randomized phase II and phase III studies of individualized treatment for nasopharyngeal carcinoma based on biomarker Epstein Barr Virus (EBV) deoxyribonucleic acid (DNA)
There are two study questions we are asking in this randomized phase II / III trial based on a blood biomarker, Epstein Barr virus (EBV) deoxyribonucleic acid (DNA) for locoregionally advanced non-metastatic nasopharyngeal cancer. All patients will first undergo standard concurrent chemotherapy and radiation therapy. When this standard treatment is completed, if there is no detectable EBV DNA in their plasma, then patients are randomized to either standard adjuvant cisplatin and fluorouracil chemotherapy or observation. If there is still detectable levels of plasma EBV DNA, patients will be randomized to standard cisplatin and fluorouracil chemotherapy versus gemcitabine and paclitaxel. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Drugs used in chemotherapy, such as cisplatin, fluorouracil, gemcitabine hydrochloride, and paclitaxel work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether giving cisplatin and fluorouracil is more effective than gemcitabine hydrochloride and paclitaxel after radiation therapy in treating patients with nasopharyngeal cancer.
Gutierrez A, Simmonds J, O’Leary M, Scott A. Partial Cricotracheal Resection with Costal Cartilage Reconstruction for Recurrent Metastatic Papillary Thyroid Carcinoma accepted for poster presentation at the American Academy of Otolaryngology – Head and Neck Surgery 2018 Annual Meeting, Atlanta, Georgia, October 2018.
Park D, Quay-de la Vallee Z, Huber K, O’Leary M, Roomian T, Farag A. Risk of Radiation-Induced Dysguesia in Smoking and Non-smoking Head and Neck Cancer Patient. Poster presentation at the 2018 American Academy of Oral Medicine meeting in San Antonio, Texas, April, 2018.
Pectoralis Major Flap with Preservation of Breast Implant, poster presentation at the Triological Society’s 2018 Combined Sections Meeting January 2018, Scottsdale, AZ.
Harb J, O’Leary MA, Rebeiz E. Breast Cancer Metastasis to the Sinuses. Poster presentation at American Academy of Otolaryngology – Head and Neck Surgery Annual Meeting, September 2017.
Kim WS, Kung J, O’Leary MA. Incidental cervical metastasis of papillary thyroid cancer without a thyroid lesion – a case series. Poster presentation, World Thyroid Congress July 2017.
Heyes R, Taki N, O’Leary M. “Vagal paraganglioma presenting as a neck mass associated with cough on palpation” Case Reports in Otolaryngology, Volume 2017 (2017), Article ID 7603814.
Kim WS, Haser EK, O’Leary MA. Laryngectomy patients in the primary care setting: Are they being cared for appropriately? Poster presentation at the 2017 American Head and Neck Society meeting, April 2017, San Diego CA.
Shah A, Dagher W, O’Leary M, Wein R. Squamous Cell Carcinoma Presenting with Trigeminal Anesthesia: An Uncommon Presentation of Head & Neck Cancer with Unknown Primary published online ahead of print in American Journal of Otolaryngology–Head and Neck Medicine and Surgery, November 2016.
Smith M, O’Leary M, Rebeiz E. “Sinonasal Lymphoma Case Series and Review of Literature” – poster at American Rhinologic Society Meeting, September 2015, Dallas TX
Alzaman N, Pittas AG, O’Leary M, Ceglia L. “Post-thyroidectomy hypocalcemia exacerbated by chyle leak”. Endocrinology, Diabetes and Metabolism Case Reports March 2015.
Farmer RW, McCall L, Civantos FJ, Myers JN, Yarbrough WG, Murphy B, O’Leary M, Zitsch R, Siegel BA. Lymphatic Drainage Patterns in Oral Squamous Cell Carcinoma: Findings of the ACOSOG Z0360 (Alliance) Study. Otolaryngology-Head & Neck Surgery 2015; 152(4):673-77.
Flis DW, Shah AT, Tracy JC, Heilman CB, O’Leary MA. Metastatic breast carcinoma of the jugular foramen: A rare case of Villaret syndrome. Head and Neck. 2015 Jan 14.
Tracy J, Mildenhall N, Wein R, O’Leary M. Breast Cancer Metastases to the Head & Neck: Case Series and Literature Review. Ear, Nose & Throat Journal accepted October 2014. PMID 28346651
Tracy J, Merdad M, O’Leary M, Wein R. Nasopharyngeal Carcinoma: An Awareness and Screening Initiative in Boston’s Chinatown. British Journal of Medicine & Medical Research 4(17): 2014
Mosesso K, Von Euw E, O’Leary M, Wein R. Tracheostomy Management Made Simple for the Head & Neck Cancer Patient. Provenir Publishing, Spokane WA, 2014.
Farmer RW, Civantos, Myers, Yarbrough, Siegel, O’Leary, Zitsch. Lymphatic Mapping Patterns in Early Oral Squamous Cell Carcinoma Otolaryngology-Head & Neck Surgery 2013, Vol 149 No 2 suppl p70.
Wein R, O’Leary M. Cancer of the Unknown Primary in Textbook of Complex Surgical Oncology, McGraw-Hill.
Mohan S, Flis DW, O’Leary MA. A case of trigemino-cardiac reflex during infrastructure maxillectomy Otolaryngology-Head & Neck Surgery June 2014 Vol 140 No 6.
Tracy J, Mukand-Cerro I, O’Leary M, Laver N, Wein R. “Bcl-2 Family Gene Expression in Oropharyngeal Squamous Cell Carcinoma”. Cancer and Clinical Oncology Vol 3, No 1, 2014.
Parekh A, Vecchiotti M, O’Leary M, Scott A. Lower island trapezius myocutaneous flap reconstruction of a large neck defect in an infant. International Journal of Pediatric Otorhinolaryngology 76 (2012) 1852-1854.
Wein R, O’Leary M. “Chapter 51: Stomatitis.” In Johnson J, Rosen C (ed) Bailey’s Head & Neck Surgery – Otolaryngology, 5th edn. Lippincott Williams & Wilkins, Philadelphia, 2014, pgs 736-756.