Practice Contact Information
Baylor College of Medicine, One Baylor Plaza MS: NA 102
Areas of Interest in Head and Neck Surgery
Endocrine Surgery, Head and Neck Research, Head and Neck Surgeon
Vlad C. Sandulache MD, PhD is a board certified otolaryngologist specializing in Head and Neck Surgical Oncology. Dr. Sandulache earned his MD and PhD from the University of Pittsburgh, and completed his residency in Otolaryngology Head and Neck Surgery at Baylor College of Medicine. Following residency, Dr. Sandulache completed a clinical fellowship in the Department of Head and Neck Surgery at the University of Texas MD Anderson Cancer Center where he received advanced training in minimally invasive surgical techniques for pharyngeal and laryngeal malignancies including transoral robotic surgery (TORS) and transoral laser surgery.Dr. Sandulache utilizes a multidisciplinary approach to the management of patients with head and neck cancer with active participation in both surgical and non-surgical clinical trials. His primary clinical expertise is in the management of early and advanced stage oropharyngeal and laryngeal cancer, salivary gland neoplasms and poorly differentiated and anaplastic thyroid carcinoma.Dr. Sandulache maintains an active basic science and clinical research program focused on elucidating the link between cancer metabolism and treatment effectiveness. The goal of this research program is to develop personalized treatment strategies based on tumor genomic information and metabolic response to conventional and targeted treatment strategies. One application of this approach currently underway is development of more effective treatments for poorly differentiated and anaplastic thyroid carcinoma.
We are currently conducting a phase I/II clinical trial evaluating the impact of metformin on clinical outcomes for patients treatment with radiation and cisplatin for stage III-IV head and neck squamous cell carcinoma. The clinical trial is currently open to enrollment and accruing patients.
1. ?Agarwala S, Cano E, Heron D, Johnson J, Myers E, Sandulache V, Bahri S, Ferris R, Wang Y, Argiris A. Long-term outcomes with concurrent carboplatin, paclitaxel and radiation therapy for locally advanced, inoperable head and neck cancer. Ann Oncol. 2007 18(7):1224-1229.2. ?Frederick MJ, VanMeter AJ, Gadhikar MA, Henderson YC, Yao H, Pickering C, Williams MD, El-Naggar AK, Sandulache VC, Tarco E, Myers JN, Clayman GL, Liotta LA, Petricoin EF III, Calvert V, Fondale V, Wand J, Weber RS. Phosphoproteomic Analysis of Signaling Pathways in Head and Neck Squamous Cell Carcinoma Patient Samples. Am J Path 2011 178(2):548-713. ?Sandulache VC, Ow TJ, Pickering, CR, Frederick MJ, Zhou G, Fokt F, Davis-Malesevich Melinda, Priebe W, Myers JN. Glucose, not Glutamine is the Dominant Energy Source Required for Proliferation and Survival of Head and Neck Squamous Carcinoma Cells. Cancer. 2011 Jul;117(13):2926-38.4. ?Sandulache VC, Skinner HD, Ow TJ, Zhang A, Xia X, Luchak JM, Wong LJ, Pickering CR, Zhou G, Myers JN. Individualizing antimetabolic treatment strategies for head and neck squamous cell carcinoma based on TP53 mutational status. Cancer. 2012 Feb; 118(3):711-215. ?Sano D, Xie TX, Ow TJ, Zhao M, Pickering CR, Zhou G, Sandulache VC, Wheeler DA, Gibbs RA, Caulin C, Myers JN. Disruptive TP53 Mutation Is Associated with Aggressive Disease Characteristics in an Orthotopic Murine Model of Oral Tongue Cancer. ? Clin Cancer Res. 2011 Nov;17(21):6658-70.6. ?Skinner HD, Sandulache VC, Ow TJ, Meyn RE, Yordy JS, Beadle BM, Fitzgerald AL, Giri U, Ang KK, Myers JN. TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence. Clin Cancer Res. 2012 Jan;18(1):290-300.7. ?Sandulache VC, Skinner HD, Wang Y, Chen YY, Dodge CT, Ow, TJ, Bankson JA, Myers JN, Lai SY. Glycolytic inhibition alters anaplastic thyroid carcinoma tumor metabolism and improves response to conventional chemotherapy and radiation. Mol Cancer Ther. 2012 Jun; 11(6):1373-80.8. ?Skinner HD, McCurdy MR, Echeverria AE, Lin SH, Welsh JW, O’Reilly MS, Hofstetter WL, Ajani JA, Komaki R, Cox JD, Sandulache VC, Myers JN, Guerrero TM. Metformin use and improved response to therapy in esophageal adenocarcinoma. Acta Oncol. 2013 Jun;52(5):1002-9.9. ?Sandulache VC, Ow TJ, Daram SP, Hamilton J, Skinner H, Bell D, Rosenthal DI, Beadle BM, Ang KK, Kies MS, Johnson FM, El-Naggar AK, Myers JN. Residual nodal disease in patients with advanced-stage oropharyngeal squamous cell carcinoma treated with definitive radiation therapy and post treatment neck dissection: Association with locoregional recurrence, distant metastasis, and decreased survival. Head Neck. 2013 Oct;35(10):1454-60.10. ?Hamilton JD, Ahmed S, Sandulache VC, Daram SP, Ow TJ, Skinner HD, Rao A, Ginsberg LE, Kumar AJ, Myers JN. Improving Imaging Diagnosis for Residual Nodal Disease after Definitive Therapy for Oropharyngeal Carcinoma: Specific Signs for CT and Best Performance of Combined Criteria, Am J Neuroradiol. 2013 Aug; 34(8):1637-42.11. ?Sandulache VC, Kubik MW, Skinner HD, Malsky JA, Gelbard AH, Zevallos JP. Impact of race/ethnicity on laryngeal cancer in patients treated at a Veterans Affairs Medical Center. Laryngoscope. 2013 Sep; 123(9):2170-5.12. ?Sandulache VC, Hamblin JS, Skinner HD, Kubik MW, Myers JN, Zevallos JP. Association between metformin use and improved survival in patients with laryngeal squamous cell carcinoma. Head Neck. 2014 Jul; 36(7):1039-43.13. ?Skinner HD, Crane C, Garrett C, Eng C, Chang G, Skibber J, Rodriguez-Bigas M, Kelly P, Sandulache V, Delclos M, Krishnan S, Das P. Metformin use and improved response to therapy in rectal cancer. Cancer Med 2013 Feb; 2(1):99-107.14. ?Ramirez MS, Lee J, Walker CM, Sandulache VC, Hennel F, Lai SY, Bankson JA. Radial Spectroscopic MRI of Hyperpolarized [1-13C] Pyruvate at 7 T. Magn Reson Med. 2014 Oct; 72(4):986-95.15. ?Sandulache VC, Chen Y, Lee J, Rubinstein A, Ramirez MS, Skinner HD, Walker CM, Williams MD, Tailor R, Court L, Bankson JA, Lai SY. Evaluation of hyperpolarized [1-13C] – pyruvate by magnetic resonance to detect ionizing radiation effects in real time. PLOS One. 2014 Jan; 9(1):e87031.16. ?Sandulache VC, Hamblin J, Lai S, Pezzi T, Skinner HD, Khan NA, Dioun SM, Hartman C, Kramer J, Chiao E, Zhou X, Zevallos JP. Oropharyngeal squamous cell carcinoma in the veteran population: Association with traditional carcinogen exposure and poor clinical outcomes. Head Neck. 2015 Sep;37(9):1246-53.17. ?Zhou G, Wang J, Zhao M, Xie TX, Tanaka N, Sano D, Patel AA, Ward AM, Sandulache VC, Jasser SA, Skinner HD, Fitzgerald AL, Osman AA, Wei Y, Xia X, Songyang Z, Mills GB, Hung MC, Caulin C, Liang J, Myers JN. Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation. Mol Cell. 2014 Jun 19; 54(6):960-74.18. ?Zevallos JP, Sandulache VC, Hamblin J, Skinner HD, Kramer J, Hartman CM, Horter KL, Lai S, Zhou X, Chiao EY. Impact of race on oropharyngeal squamous cell carcinoma presentation and outcomes among veterans. Head Neck. 2014 [Epub ahead of print].19. ?Fitzgerald AL, Osman AA, Xie TX, Patel A, Skinner H, Sandulache V, Myers JN. Reactive oxygen species and p21Waf1/Cip1 are both essential for p53-mediated senescence of head and neck cancer cells. Cell Death Dis. 2015 Mar 12;6:e1678.20. ?Sandulache VC, Chen Y, Skinner HD, Lu T, Feng L, Court LE, Myers JN, Meyn RE, Fuller CD, Bankson JA, Lai SY. Acute tumor lactate perturbations as a biomarker of genotoxic stress: development of a biochemical model. Mol Cancer Ther. 2015 Dec;14(12):2901-8.21. ?Jaehyuk Lee J, Ramirez MS, Walker CM, Chen Y, Yi S, Sandulache VC, Lai, SY, Bankson JA. High-throughput hyperpolarized 13C metabolic investigations using a multi-channel acquisition system. J Magn Reson. 2015 Nov; 260:20-7.22. ?Bankson JA, Walker CM, Ramirez MS, Stefan W, Fuentes D, Merritt ME, Lee J, Sandulache VC, Chen Y, Phan L, Chou PC, Rao A, Yeung SC, Lee MH, Schellingerhout D, Conrad CA, Malloy C, Sherry AD, Lai SY, Hazle JD. Kinetic modeling and constrained reconstruction of hyperpolarized [1-13C]-pyruvate offers improved metabolic imaging of tumors. Cancer Res. 2015 Nov 15; 75(22):4708-17.23. ?Messer JA, Mohamed AS, Hutcheson KA, Ding Y, Lewin JS, Wang J, Lai SY, Frank SJ, Garden AS, Sandulache V, Eichelberger H, French CC, Colen RR, Phan J, Kalpathy-Cramer J, Hazle JD, Rosenthal DI, Gunn GB, Fuller CD. Magnetic resonance imaging of swallowing-related structures in nasopharyngeal carcinoma patients receiving IMRT: Longitudinal dose-response characterization of quantitative signal kinetics. Radiother Oncol. 2016 Feb; 118(2):315-22.24. ?Pezzi TA, Sandulache VC, Pezzi CM, Turkeltaub AE, Feng L, Cabanillas ME, Williams MD, Lai SY. Treatment and survival of patients with insular thyroid carcinoma: 508 cases from the National Cancer Data Base. Head Neck. 2016 Jun; 38(6):906-12.25. ?Sandulache VC, Vandelaar LJ, Skinner HD, Cata J, Hutcheson K, Fuller CD, Phan J, Siddiqui Z, Lai SY, Weber RS, Zafereo ME. Salvage total laryngectomy after external-beam radiotherapy: A 20-year experience. Head Neck. 2016 Apr; 38 Suppl 1:E1962-8.26. ?Lai S, Wenaas AE, Sandulache VC, Hartman C, Chiao E, Kramer J, Zevallos JP. Prognostic Significance of p16 Cellular Localization in Oropharyngeal Squamous Cell Carcinoma. Ann Clin Lab Sci. 2016 Mar; 46(2):132-9.27. ?Sandulache VC, Hobbs BP, Mohamed AS, Frank SJ, Song J, Ding Y, Ger R, Court LE, Kalpathy-Cramer J, Hazle JD, Wang J, Awan MJ, Rosenthal DI, Garden AS, Gunn GB, Colen RR, Elshafeey N, Elbanan M, Hutcheson KA, Lewin JS, Chambers MS, Hofstede TM, Weber RS, Lai SY, Fuller CD. Dynamic contrast-enhanced MRI detects acute radiotherapy-induced alterations in mandibular microvasculature: prospective assessment of imaging biomarkers of normal tissue injury. Sci Rep. 2016 Aug 8;6:29864