Investigator NameRichard Wong
Investigator Phone(212) 639-7638
New York, NY 10021
- Cell signaling
- Tumor biology
- Molecular & cell biology
- Tumor progression and metastases
- Animal models
Perineural invasion (PNI) is an ominous form of cancer progression in which cancer cells invade and track along nerves. PNI occurs most frequently in cancers that affect highly innervated organs, including pancreatic, head and neck, and prostate cancers. It is associated with increased recurrence and poor prognosis.
Our laboratory focuses on elucidating the molecular and cellular mechanisms involved in the process of PNI. We have identified a variety of ligand receptor-mediated interactions between cancer cells and the nerve microenvironment that reflect active communication and facilitate PNI. We have also demonstrated that activated Schwann cells recruit and disperse cancer cells, promoting invasive behavior along nerves.
We explore how PNI is enabled by reciprocal interactions between cancer cells and the nerve microenvironment. Ultimately, we aim to translate these discoveries into novel therapies aimed at interrupting this aggressive form of cancer progression.
|pLVX-EF1a-Luciferase-IRES-ZsGreen||Co-expression of luciferase and fluorescent protein for both in vivo and in vitro imaging.|
|Area of Expertise||Protocol Provided||Training Available|
|Small animal surgery including sciatic nerve injection, intra-pancreatic (head or tail) injection, salivary gland (submandibular and parotid gland) injection, cervical sympathetic ganglionectomy, subphrenic bilateral vagotomy, pyloroplasty.||Yes||Yes|