AHNS Mucosal Malignancy Section Edition

The AHNS Journal Club regularly reviews the leading head and neck cancer-related journals, sharing with AHNS members some of the most relevant and important manuscripts, and providing summaries and critiques of the work.

This month’s issue of the AHNS Journal Club has been compiled and reviewed by members of the AHNS Mucosal Malignancy Section (Karen Pitman, Chair; Joe Califano, Co-Chair): 

Jeffson Chung
Stephen Lai
Vikas Mehta
Arun Sharma
Meghan Turner

Radiotherapy versus transoral robotic surgery and neck dissection for oropharyngeal squamous cell carcinoma (ORATOR): an open-label, phase 2, randomised trial

Anthony C Nichols, Julie Theurer, Eitan Prisman, Nancy Read, Eric Berthelet, Eric Tran, Kevin Fung, John R de Almeida, Andrew Bayley, David P Goldstein, Michael Hier, Khalil Sultanem, Keith Richardson, Alex Mlynarek, Suren Krishnan, Hien Le, John Yoo, S Danielle MacNeil, Eric Winquist, J Alex Hammond, Varagur Venkatesan, Sara Kuruvilla, Andrew Warner, Sylvia Mitchell, Jeff Chen, Martin Corsten, Stephanie Johnson-Obaseki, Libni Eapen, Michael Odell, Christina Parker, Bret Wehrli, Keith Kwan, David A Palma

from The Lancet, August 2019

Phase II Trial of De-Intensified Chemoradiotherapy for Human Papillomavirus–Associated Oropharyngeal Squamous Cell Carcinoma

Chera BS, Amdur RJ, Green R, Shen C, Gupta G, Tan X, Knowles M, Fried D, Hayes N, Weiss J, Grilley-Olson J, Patel S, Zanation A, Hackman T, Zevallos J, Blumberg J, Patel S, Kasibhatla M, Sheets N, Weissler M, Yarbrough W, Mendenhall W.

 from The Journal of Clinical Oncology, August 2019

Assessment of the Rate of Skip Metastasis to Neck Level IV in Patients With Clinically Node-Negative Neck Oral Cavity Squamous Cell Carcinoma: A Systematic Review and Meta-analysis

Anton Warshavsky, MD; Roni Rosen, BS; Narin Nard-Carmel, MD; Sara Abu-Ghanem, MD; Yael Oestreicher-Kedem, MD; Avraham Abergel, MD; DanM. Fliss, MD; Gilad Horowitz, MD

From JAMA Otolaryngology – Head and Neck Surgery, June 2019

Prognostic Role of p16 in Nonoropharyngeal Head and Neck Cancer.

Bryant AK, Sojourner EJ, Vitzthum LK, Zakeri K, Shen H, Nguyen C, Murphy JD, Califano JA, Cohen EEW, Mell LK.

from Journal of the National Cancer Institute, December 2018

Gemcitabine and Cisplatin Induction Chemotherapy in Nasopharyngeal Carcinoma.

Zhang Y, Chen L, Hu GQ, Zhang N, Zhu XD, Yang KY, Jin F, Shi M, Chen YP, Hu WH, Cheng ZB, Wang SY, Tian Y, Wang XC, Sun Y, Li JG, Li WF, Li YH, Tang LL, Mao YP, Zhou GQ, Sun R, Liu X, Guo R, Long GX, Liang SQ, Li L, Huang J, Long JH, Zang J, Liu QD, Zou L, Su QF, Zheng BM, Xiao Y, Guo Y, Han F, Mo HY, Lv JW, Du XJ, Xu C, Liu N, Li YQ, Chua MLK, Xie FY, Sun Y, Ma J

from The New England Journal of Medicine, September 2019

Eliminating Postoperative Radiation to the Pathologically Node-Negative Neck: Long-Term Results of a Prospective Phase II Study

Contreras JA, Spencer C, DeWees T, Haughey B, Henke LE, Chin RI, Paniello R, Rich J, Jackson R, Oppelt P, Pipkorn P, Zevallos J, Chernock R, Nussenbaum B, Daly M, Gay H, Adkins D, Thorstad W.

from the Journal of Clinical Oncology, October 2019