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• Endocrine Surgery
• Head and Neck Research
• Head and Neck Surgeon

9228 Medical Plaza Drive
Charleston, South Carolina 29406
United States
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hcahealthcareheadandneck.com

David M. Neskey, M.D., MSCR, FACS is a head and neck surgeon and serves as the national director of research for head and oncology for Sarah Cannon Research Institute.  Originally from Massachusetts he received his medical degree from Albany Medical College with a distinction in research in 2006 followed by a residency in Otolaryngology Head and Neck Surgery at the University of Miami.  He then completed a fellowship in head and neck surgical oncology at MD Anderson Cancer Center in Houston.  This training experience was comprised of two years dedicated to basic science research followed by a year committed to the management of patients with head and neck cancer.

Dr Neskey’s clinical focus is on the care of patients with benign and malignant neoplasias of the head and neck including oral cavity, oropharyngeal, laryngeal lesions, and skullbase,  advanced melanoma and nonmelanoma skin cancers, and lesions of the salivary glands, thyroid and parathyroids.  His specific interests are squamous cell carcinoma of the oral cavity and oropharynx along with advanced skin cancer and skull base tumors.  He currently sees patients at HCA Healthcare Head and Neck Specialists in Charleston and Greenville, South Carolina.

Dr Neskey has published over 60 peer reviewed articles and book chapters focused on the molecular pathways and genomic alterations associated with head and neck squamous cell carcinoma.  Based on this work he is currently funded through the National Institute of Health to study the mechanisms of invasion and metastases in head and neck cancer.  He is board certified by the American Board of Otolaryngology and is a member of the American Head and Neck Society, American Academy of Clinical Research, and a Fellow of the American College of Surgeons.

NCT04564989

Prospective Observational Study to Validate Circulating HPVDNA and Prognostic Genomic Biomarkers in HPV-associated OPSCC.

Role: Co-investigotar

Theodossiou Z, Ansley J, Neskey D, Day T, Sharav S HPV-Associated Oropharyngeal Cancer in Patients With Chronic Lymphocytic Leukemia. Laryngoscope. 2025 Jun 9. doi: 10.1002/lary.32311. Online ahead of print.PMID: 40485637

Sharav S, Horton JD, Theodossiou Z, Turner J, Neskey DM, Day T. HPV-Associated Head and Neck Second Primary Tumors-A Case Series. Head Neck. 2025 Mar;47(3):E32-E35. doi: 10.1002/hed.28018. Epub 2024 Nov 27.PMID: 39601195

 

Horwich P, Sivarajah S, Neskey DM, Hornig J Applications of Synthetic Hybrid-Scale Fiber Matrix in Head and Neck Reconstruction: A Case Series. Case Rep Oncol. 2024 Jun 7;17(1):622-629. doi: 10.1159/000539200. eCollection 2024 Jan-Dec.PMID: 39015642

 

Froehlich MH, Shih MC, Shehee L, Kompelli AR, Aylward A, Nguyen SA, Kaczmar JM, Nathan CA, Day T, Neskey DM. Systematic review of neuroendocrine carcinomas of the oropharynx. Head Neck. 2022 Jul;44(7):1725-1736. doi: 10.1002/hed.27055. Epub 2022 Apr 18.PMID: 35437851.

 

Levy DA, Patel JJ, Nguyen SA, Nicholas Jungbauer W, Neskey DM, Cohen EEW, Paulos CM, Kaczmar JA, Knochelmann HM, Day TA. Programmed death 1 (PD-1) and ligand (PD-L1) inhibitors in head and neck squamous cell carcinoma: A meta-analysis.

World J Otorhinolaryngol Head Neck Surg. 2022 Apr 18;8(3):177-186. doi: 10.1002/wjo2.15. eCollection 2022 Sep.PMID: 36159902.

 

Contrera KJ, Zafereo ME, Yaniv D, Roberts DB, Gillenwater AM, Hanna EY, Weber RS, Myers JN, Chang EI, Garvey PB, Hanasono MM, Yu P, Hutcheson KA, Fuller CD, Tyler MA, Neskey DM. Outcomes for recurrent oral cavity squamous cell carcinoma.

Oral Oncol. 2022 Nov;134:106127. doi: 10.1016/j.oraloncology.2022.106127. Epub 2022 Sep 23.PMID: 36155359

 

Riesenberg BP, Hunt EG, Tennant MD, Hurst KE, Andrews AM, Leddy LR, Neskey DM, Hill EG, Rivera GOR, Paulos CM, Gao P, Thaxton JE. Stress-Mediated Attenuation of Translation Undermines T-cell Activity in Cancer. Cancer Res. 2022 Dec 2;82(23):4386-4399. doi: 10.1158/0008-5472.CAN-22-1744.PMID: 36126165

 

Smith AS, Knochelmann HM, Wyatt MM, Rangel Rivera GO, Rivera-Reyes AM, Dwyer CJ, Ware MB, Cole AC, Neskey DM, Rubinstein MP, Liu B, Thaxton JE, Bartee E, Paulos CM. B cells imprint adoptively transferred CD8⁺ T cells with enhanced tumor immunity.

.J Immunother Cancer. 2022 Jan;10(1):e003078. doi: 10.1136/jitc-2021-003078.PMID: 35017148

 

Kompelli AR, Froehlich MH, Morgan PF, Li H, Sharma AK, Nathan CO, Neskey DM. Definitive Radiotherapy versus Surgery for the Treatment of Verrucous Carcinoma of the Larynx: A National Cancer Database Study. Int Arch Otorhinolaryngol. 2021 Nov 3;26(3):e348-e356. doi: 10.1055/s-0041-1730304. eCollection 2022 Jul.PMID: 35846806

 

Knochelmann HM, Horton JD, Liu S, Armeson K, Kaczmar JM, Wyatt MM, Richardson MS, Lomeli SH, Xiong Y, Graboyes EM, Lentsch EJ, Hornig JD, Skoner J, Stalcup S, Spampinato MV, Garrett-Mayer E, O'Quinn EC, Timmers CD, Romeo MJ, Wrangle JM, Young MRI, Rubinstein MP, Day TA, Lo RS, Paulos CM, Neskey DM. Neoadjuvant presurgical PD-1 inhibition in oral cavity squamous cell carcinoma. Cell Rep Med. 2021 Oct 19;2(10):100426. doi: 10.1016/j.xcrm.2021.100426. eCollection 2021 Oct 19. PMID: 34755137

 

Knochelmann HM, Rivera-Reyes AM, Wyatt MM, Smith AS, Chamness R, Dwyer CJ, Bobian M, Rangel Rivera GO, Horton JD, Lilly M, Romeo MJ, Timmers CD, Rubinstein MP, Neskey DM, Paulos CM. Modeling ex vivo tumor-infiltrating lymphocyte expansion from established solid malignancies. Oncoimmunology. 2021 Aug 12;10(1):1959101. doi: 10.1080/2162402X.2021.1959101. eCollection 2021.PMID: 34408920

 

Yan F, Li H, de Almeida JR, Kaczmar JM, Pipkorn P, Zenga J, Richardson MS, Neskey DM, Sharma AK, Day TA, Graboyes EM. Microscopic Extranodal Extension in HPV-Negative Head and Neck Cancer and the Role of Adjuvant Chemoradiation. Otolaryngol Head Neck Surg. 2021 Oct;165(4):536-549. doi: 10.1177/0194599821989637. Epub 2021 Feb 23.PMID: 33618570

 

Mehta NK, Li AR, Nguyen SA, Kaczmar JM, Neskey DM, Day TA. Immune Checkpoint Inhibitors for Advanced Cutaneous Squamous Cell Carcinoma: A Systematic Review with Meta-Analysis. Target Oncol. 2021 Nov;16(6):743-752. doi: 10.1007/s11523-021-00844-z. Epub 2021 Oct 22.PMID: 34677815

 

Liu S, Knochelmann HM, Lomeli SH, Hong A, Richardson M, Yang Z, Lim RJ, Wang Y, Dumitras C, Krysan K, Timmers C, Romeo MJ, Krieg C, O'Quinn EC, Horton JD, Dubinett SM, Paulos CM, Neskey DM, Lo RS. Response and recurrence correlates in individuals treated with neoadjuvant anti-PD-1 therapy for resectable oral cavity squamous cell carcinoma.

Cell Rep Med. 2021 Oct 19;2(10):100411. doi: 10.1016/j.xcrm.2021.100411. eCollection 2021 Oct 19.PMID: 34755131

 

Graboyes EM, Sterba KR, Li H, Warren GW, Alberg AJ, Calhoun EA, Nussenbaum B, McCay J, Marsh CH, Osazuwa-Peters N, Neskey DM, Kaczmar JM, Sharma AK, Harper J, Day TA, Hughes-Halbert C. Development and Evaluation of a Navigation-Based, Multilevel Intervention to Improve the Delivery of Timely, Guideline-Adherent Adjuvant Therapy for Patients With Head and Neck Cancer. JCO Oncol Pract. 2021 Oct;17(10):e1512-e1523. doi: 10.1200/OP.20.00943. Epub 2021 Mar 10.PMID: 33689399

Dwyer CJ, Arhontoulis DC, Rangel Rivera GO, Knochelmann HM, Smith AS, Wyatt MM, Rubinstein MP, Atkinson C, Thaxton JE, Neskey DM, Paulos CM. Ex vivo blockade of PI3K gamma or delta signaling enhances the antitumor potency of adoptively transferred CD8⁺ T cells. Eur J Immunol. 2020 May 8. doi: 10.1002/eji.201948455. Online ahead of print.PMID: 32383488

Gupta A, Koochakzadeh S, Neskey DM, Nguyen SA, Lentsch EJ. Incidence and survival trends of parotid malignancies over 42 years. Head Neck. 2020 Apr 21. doi: 10.1002/hed.26172. Online ahead of print.PMID: 32314846

Xiong Y, Neskey DM, Horton JD, Paulos CM, Knochelmann HM, Armeson KE, Young MRI. Immunological effects of nivolumab immunotherapy in patients with oral cavity squamous cell carcinoma. BMC Cancer. 2020 Mar 17;20(1):229. doi: 10.1186/s12885-020-06726-3.PMID: 32183719

Graboyes EM, Hill EG, Marsh CH, Maurer S, Day TA, Hornig JD, Lentsch EJ, Neskey DM, Skoner J, Sterba KR. Temporal Trajectory of Body Image Disturbance in Patients with Surgically Treated Head and Neck Cancer. Otolaryngol Head Neck Surg. 2020 Jan 7:194599819898861. doi: 10.1177/0194599819898861

Gupta A, Koochakzadeh S, Neskey DM, Nguyen SA, Lentsch EJ. Carcinoma ex pleomorphic adenoma: A review of incidence, demographics, risk factors, and survival. Am J Otolaryngology. 2019 Aug 21:102279.

Gupta A, Koochakzadeh S, Neskey DM, Nguyen SA, Lentsch EJ. Salivary Carcinosarcoma: An Extremely Rare and Highly Aggressive Malignancy. Laryngoscope. 2019 Jul 10.

Horton JD, Knochelmann HM, Day TA, Paulos CM, Neskey DM. Immune Evasion by Head and Neck Cancer: Foundations for Combination Therapy. Trends in Cancer. 2019, Vol. 5(4):208-232

Kompelli AR, Ni JS, Nguyen SA, Lentsch EJ, Neskey DM, Meyer TA. The outcomes of hypoglossal nerve stimulation in the management of OSA: A systematic review and meta-analysis. World J Otorhinolaryngol Head Neck Surg. 2018 Sep 25;5(1):41-48. doi: 10.1016/j.wjorl.2018.04.006. eCollection 2019 Mar. Review.

Janz TA, Neskey DM, Nguyen SA, Lentsch EJ. Is the incidence of anaplastic thyroid cancer increasing: A population based epidemiology study. World J Otorhinolaryngol Head Neck Surg. 2018 Aug 11;5(1):34-40. doi: 10.1016/j.wjorl.2018.05.006. eCollection 2019 Mar. Review

Kompelli AR, Morgan P, Li H, Harris W, Day TA, Neskey DM. Prognostic Impact of High-Risk Pathologic Features in HPV-Related Oropharyngeal Squamous Cell Carcinoma and Tobacco Use. Otolaryngol Head Neck Surg. 2018 Dec 11:194599818818446. doi: 10.1177/0194599818818446. [Epub ahead of print]

Graboyes EM, Kompelli AR, Neskey DM, Brennan E, Nguyen S, Sterba KR, Warren GW, Hughes-Halbert C, Nussenbaum B, Day TA. Association of Treatment Delays With Survival for Patients With Head and Neck Cancer: A Systematic Review. JAMA Otolaryngol Head Neck Surg. 2018 Nov 1. doi: 10.1001/jamaoto.2018.2716. [Epub ahead of print] PMID:30383146

Kompelli AR, Li H, Neskey DM. Impact of Delay in Treatment Initiation on Overall Survival in Laryngeal Cancers. Otolaryngol Head Neck Surg. 2018 Oct 16:194599818803330. doi: 10.1177/0194599818803330. [Epub ahead of print] PMID:30322343

Semelakova M, Grauzam S, Betadthunga P, Tiedeken J, Coaxum S, Neskey DM, Rosenzweig SA. Vimentin and Non-Muscle Myosin IIA are Members of the Neural Precursor Cell Expressed Developmentally Down-Regulated 9 (NEDD9) Interactome in Head and Neck Squamous Cell Carcinoma Cells. Transl Oncol. 2018 Sep 26;12(1):49-61. doi: 10.1016/j.tranon.2018.09.006. [Epub ahead of print] PMID:30267961

Janz TA, Graboyes EM, Nguyen SA, Ellis MA, Neskey DM, Harruff EE, Lentsch EJ. A Comparison of the NCDB and SEER Database for Research Involving Head and Neck Cancer. Otolaryngol Head Neck Surg. 2018 Aug 21:194599818792205. doi: 10.1177/0194599818792205. [Epub ahead of print] PMID: 30129822

Metastatic Salivary Ductal Carcinoma to the Mastoid Segment of the Facial Nerve. Fabie JE, Hatch JL, Cross AW, Oyer SL, Neskey DM, McRackan TR. Otol Neurotol. 2018 Jul 30. doi: 0.1097 PMID: 30063500

Janz TA, Neskey DM, Nguyen SA, Lentsch EJ. Is imaging of the brain necessary at diagnosis for cutaneous head and neck melanomas? Am J Otolaryngol. 2018 Jun 8. pii: S0196-0709(18)30415-0. doi: 10.1016/j.amjoto.2018.06.007. [Epub ahead of print] Review. PMID: 29929862

Grauzam S, Brock AM, Holmes CO, Tiedeken JA, Boniface SG, Pierson BN, Patterson DG, Coaxum SD, Neskey DM, Rosenzweig SA. NEDD9 stimulated MMP9 secretion is required for invadopodia formation in oral squamous cell carcinoma. Oncotarget. 2018 May 22;9(39):25503-25516. doi: 10.18632/oncotarget.25347. eCollection 2018 May 22. PMID: 29876004

Preoperative Predictors of Occult Nodal Disease In cT1N0 Oral Cavity Squamous Cell Carcinoma: Review Of 2623 Cases.  Zhan KY, Morgan PF, Neskey DM, Kim JJ, Huang AT, Garrett-Mayer E, Day TA. Head Neck. 2018 May 14. doi: 10.1002/hed.25178. PMID: 29761586

Ellis MA, Graboyes EM, Wahlquist AE, Neskey DM, Kaczmar JM, Schopper HK, Sharma AK, Morgan PF, Nguyen SA, Day TA.  Primary Surgery vs Radiotherapy for Early Stage Oral Cavity Cancer. Otolaryngol Head Neck Surg. 2017 Dec 1:194599817746909 doi: 10.1177/0194599817746909. PMID: 29256326

Borucki RB, Neskey DM, Lentsch EJ. Malignant Fibrous Histiocytoma: Database Review Suggests a Favorable Prognosis in the Head and Neck. Laryngoscope. 2017 Oct 8. doi10.1002/lary.26909. PMID: 28988458

Ellis MA, Graboyes EM, Day TA, Neskey DM. Prognostic Factors and Occult Nodal Disease in Carcinoma of the Oral Cavity and Oropharynx: An Analysis of the National Mucoepidermoid Cancer Database.  Oral Oncol. 2017 Sep; 72:174-178. doi:10.1016/j.oraloncology.2017.07.025. Epub 2017 Jul 27.  PMID: 28797455

Lohia S, Momin S, Richardson MS, Neskey DM.  Intravascular Papillary Endothelial Hyperplasia of the Neck: A Case Report. OTO Open https://doi.org/10.1177/2473974X17699795.April 19, 2017

Coaxum SD, Tiedeken J, Garrett-Mayer E, Myers JN, Rosenzweig SA, Neskey DM. The Tumor Suppressor Capability of p53 is Dependent on Non-Muscle Myosin IIA in Head and Neck Cancer. Oncotarget. 2017 Jan. doi:10.18632/oncotarget.14967. PMID: 28160562

Ellis MA, Gerry DR, Neskey DM, Lentsch EJ.  Ewing Sarcoma of the Head and Neck. Ann Otol Rhinol Laryngol. 2017 Mar; 126(3):179-184. doi: 10.1177/0003489416681322. PMID: 28056517

Majumder M, House R, Palanisamy N, Qie S, Day TA, Neskey DM, Diehl JA, Palanisamy V. RNA-Binding Protein FXR1 Regulates p21 and TERC RNA to Bypass p53-Mediated Cellular Senescence in OSCC. PLoS Genet. 2016 Sep 8; 12(9):e1006306. doi: 10.1371/journal.pgen.1006306. PMID: 27606879

*Osman AA, Neskey DM, Katsonis P, Patel AA, Ward AM, Hsu TK, Hicks SC, McDonald TO, Ow TJ, Ortega Alves M, Pickering CR, Skinner HD, Zhao M, Sturgis EM, Kies MS, El-Naggar A, Perrone F, Licitra L, Bossi P, Kimmel M, Frederick MJ, Lichtarge O, Myers JN.  Evolutionary Action Score of TP53 Coding Variants (EAp53) is Predictive of Platinum Response in Head and Neck Cancer Patients.  Cancer Res. 2015 Feb 17. pii: canres.2729.2014. * Denotes shared first author

Neskey DM, Osman AO, Ow TJ, Dr., Katsonis P , McDonald T, Hicks SC, Hsu TK, Pickering CR, Ms. Ward A, Patel A, Yordy JS, Skinner HD, Giri U, Sano D, Story MD, Beadle BM, El-Naggar AK, Kies MS, William WN, Caulin C, Frederick M, Kimmel M, Myers, JN, Lichtarge O.  Evolutionary Action Score of TP53 (EAp53) Identifies High Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer. Cancer Research 2015 Jan 29. pii: canres.2735.2014.

Osman AA, Monroe MM, Ortega Alves MV, Patel AA, Katsonis P, Fitzgerald AL, Neskey DM, Frederick MJ, Woo SH, Caulin C, Hsu TK, McDonald TO, Kimmel M, Meyn RE, Lichtarge O, Myers JN.  Wee-1 Kinase Inhibition Overcomes Cisplatin Resistance Associated with High Risk TP53 Mutations in Head and Neck Cancer through Mitotic Arrest Followed by Senescence.  Mol Cancer Ther. 2014 Dec 10. pii: molcanther.0735.2014.

Pickering CR, Zhang J, Neskey DM, Zhao M, Jasser SA, Wang J, Ward A, Tsai CJ, Ortega Alves MV, Zhou JH, Drummond JA, El-Naggar AK, Gibbs RA, Weinstein JN, Wheeler DA, Wang J, Frederick MJ, Myers JN.  Squamous Cell Carcinoma of the Oral Tongue in Young Non-smokers is Genomically Similar to Tumors in Older Smokers.  Clin Cancer Res. 2014 May 29. pii: clincanres.0565.2014. [Epub ahead of print].

Neskey DM, Klein JD, Hicks S, Garden AS, Bell D, El-Naggar AK, Kies MS, Weber RS, Kupferman ME.  Prognostic Factors Associated Decreased Survival in Acinic Cell Carcinoma.  JAMA Otolaryngol Head Neck Surg. 2013 Sep 26. doi: 10.1001/jamaoto.2013.4728

Gadhikar MA, Sciuto MR, Ortega Alves MV, Pickering CR, Osman AA, Neskey DM, Zhao M, Fitzgerald AL, Myers JN, Frederick MJ.  Chk1/2 inhibition overcomes the cisplatin resistance of head and neck cancer cells secondary to the loss of functional p53.  Mol Cancer Ther. Mol Cancer Ther. 2013 Sep;12(9):1860-73.

Yang CZ, Ma J, Luo QQ, Neskey DM, Zhu DW, Liu Y, Myers JN, Zhang CP, Zhang ZY, Zhong LP.  Elevated level of serum growth differentiation factor 15 is associated with oral leukoplakia and oral squamous cell carcinoma.  J Oral Pathol Med. 2013 May 26. doi: 10.1111/jop.12091. [Epub ahead of print].

Pickering CR, Zhang J Suk, Yoo SY, Neskey DM, Xie TX, El-Naggar AK, Weinstein JN, Wang J, Gibbs RA, Wheeler DA, Myers JN, Frederick MJ.  Integrated genomic characterization of oral cavity squamous cell carcinoma identifies frequent genomic drivers.  Cancer Discovery.  2013 Apr 25. [Epub ahead of print].

Perez A, Neskey DM, Wen J, Pereira L, Reategui EP, Goodwin WJ, Carraway KL, Franzmann EJ.  CD44 interacts with EGFR and promotes head and neck squamous cell carcinoma initiation and progression.  Oral Oncol. 2013 Apr;49(4):306-13.  Epub 2012 Dec 20.

Eloy JA, Neskey DM, Vivero RJ, Ruiz JW, Choudhry OJ, Casiano RR.  High-resolution computed tomography analysis of the frontal sinus ostium: A pilot study.  Am J Otolaryngol. 2013 Mar; 34(2):99-102. Epub 2012 Oct 23.

Ma J, Liu Y, Huang XL, Zhang ZY, Myers JN, Neskey DM, Zhong LP.  Induction chemotherapy decreases the rate of distant metastasis in patients with head and neck squamous cell carcinoma but does not improve survival or locoregional control: A meta-analysis.  Oral Oncol. 2012 Jul 14. Epub ahead of print

Neskey DM, Hatoum G, Modh R, Civantos F, Telischi FF, Angeli S, Weed D, Sargi Z.  Outcomes after surgical resection of head and neck paragangliomas: A review of 61 patients.  Skull Base.  21:171-76, 2011

Lee SL, Neskey DM, Mouzakes J.  Potential predisposition for nasal septal perforation with methotrexate use: report of 2 cases and literature review.  Ear Nose Throat J.  88(8):12-4, 2009.

Neskey DM, Ambesi AA, Pumiglia KM, McKeown-Longo PJ.  Endostatin and anastellin inhibit distinct aspects of the angiogenic process.  J Exp Clin Cancer Res. 27:61-68, 2008 November.

Gross KL, Neskey DM, Manchanda N, Weremowicz S, Kleinman MS, Nowak RA, Ligon AH, Rogalla P, Drechsler K, Bullerdiek J, Morton CC.  HMGA2 expression in uterine leiomyomata and myometrium: quantitative analysis and tissue culture studies.  Genes, Chromosomes, & Cancer.  38(1):68-79, 2003 September.

Quade BJ, Weremowicz S, Neskey DM, Vanni R, Ladd C, Dal Cin P, Morton CC.  Fusion transcripts involving HMGA2 are not a common molecular mechanism on uterine leiomyomata with rearrangements in 12q15.  Cancer Research.  63(6):1351-8, 2003 March.

Dal Cin P, Quade BJ, Neskey DM, Kleinman MS, Weremowicz S, Morton CC.  Intravenous leiomyomatosis is characterized by a der(14)t(12;14)(q15;q24).  Genes, Chromosomes, & Cancer.  36(2):05-6, 2003 February.

Quade BJ, Dal Cin P, Neskey DM, Weremowicz S, Morton CC.  Intravenous Leiomyomatosis: molecular and cytogenetic analysis of a case.  Modern Pathology.  15(3):351-6, 2002 March.

Nucci MR, Weremocicz S, Neskey DM, Sornberger K, Tallini G, Morton CC, Quade BJ.  Chromosomal Translocation t(8;12) Induces Aberrant HMGIC Expression in Aggressive Angiomyxomas of the Vulva.  Genes, Chromosomes, and Cancer.  32(2):172 -176, 2001 October.