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Sarah Nyirjesy
Boston University Medical Center
- Endocrine Surgery
- Head and Neck Research
- Head and Neck Surgeon
- Reconstructive Head & Neck Surgery
830 Harrison Ave
Moakley Building, Suite 1400
Boston, Massachusetts 02118
United States
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Head and Neck Oncologic and Reconstructive Surgeon
and Microvascular Reconstructive Surgery at Harvard/Mass Eye and Ear.
Dr. Sarah Nyirjesy welcomes referrals for the full spectrum of adult head and neck conditions. She specializes in the management of benign and malignant lesions of the head and neck including mucosal, salivary gland, cutaneous, and endocrine tumors. She has expertise in minimally invasive transoral robotic surgery (TORS) for oropharyngeal cancer and is trained in complex head and neck reconstruction with both locoregional and microvascular free flaps. She offers advanced surgical management of thyroid and parathyroid disease, including minimally invasive robotic thyroidectomy. Dr. Nyirjesy also is certified in hypoglossal nerve stimulator implantation for patients with obstructive sleep apnea. She has experience with the surgical management of Eagle’s syndrome, paragangliomas, and other challenging head and neck disorders. Her research background includes 3D printing and the design of patient-specific medical devices.
She is currently seeing patients at 830 Harrison Ave, Moakley Building, 1st Floor, Suite 1400 in Boston, MA 02118. For referrals or consultations, Dr. Nyirjesy can be reached at [email protected] or 617.414.4913.
- Chugh C, Nyirjesy S, Nawalinski K, Sandmark DK, Frangos S, Maloney-Wilensky E, Stein SC, Levine JM, Kasner SE, Kumar MA. Red blood cell distribution width is associated with poor clinical outcome after subarachnoid hemorrhage: a pilot study. Neurocrit Care 2015;23(2):217-24. PMID: 25672971.
- Nyirjesy SC, Rodman C, Tamati T, Moberly A. Are there real-world benefits to bimodal listening? Otol Neurotol 2020;41(9):e1111-7. PMID: 32925846.
- Tamaki A, Nyirjesy S, Cabrera CI, Lancione P, Hatef A, Rice R, Zhao S, Kang SY, Ozer E, Agrawal A, Old MO, Seim NB. Treatment decision and estimation of growth of head and neck paragangliomas. Am J Otolaryngol 2022;43(2):103357. PMID: 34972002.
- Liu L, Dharmadhikari S, Spector BM, Tan ZH, Van Curen CE, Agarwal R, Nyirjesy S, Shontz K, Sperber SA, Breuer CK, Zhao K, Reynolds SD, Manning A, VanKoevering KK, Chiang T. Tissue-engineered composite tracheal grafts create mechanically stable and biocompatible airway replacements. J Tissue Eng 2022;13:20417314221108791. PMID: 35782992.
- Talbot NL, Heller MA, Nyirjesy S, Kim B, DeSilva B, Matrka L. Superior Laryngeal Nerve Block Response Rates in 54 Neurogenic Cough Patients. Laryngoscope 2023;133(10):2647–2653. PMID: 35243612.
- Daoud GE, von Windheim N, Alfayez Y, Michaels RE, Nyirjesy S, Chinn SB, Spector ME, VanKoevering KK. The Larry Tube: Customized 3D Printed Laryngectomy Tubes Following Total Laryngectomy. Ann Otol Rhinol Laryngol 2023;132(11):1477–1482. PMID: 36852947.
- Kelly NA, Althubaiti A, Katapadi AD, Smith AG, Nyirjesy SC, Yu JH, Onwuka AJ, Chiang T. Association of vibrotactile biofeedback with reduced ergonomic risk for surgeons during tonsillectomy. JAMA Otolaryngol Head Neck Surg 2023;149(4):350-356. PMID: 36976663.
- Nyirjesy SC, Fenberg R, Heller MA, Judd RT, Li MM, Koch B, Bonomi M, Carrau RL, VanKoevering KK. Response to induction chemotherapy in sinonasal malignancies: A single-institutional experience. Head Neck 2023;45(6):1445–1454. PMID: 36976815.
- Nyirjesy SC, Zhao S, Judd R, McCrary H, Kuhar HN, Farlow JL, Seim NB, Rocco JW, Kang SY, Haring CT. Hypothyroidism as an Independent Predictor of 30-day Readmission in Head and Neck Cancer Patients. Laryngoscope 2023;133(11):2988–2998. PMID: 36974971.
- Nyirjesy SC, Judd RT, Alfayez Y, Lancione P, Swendseid B, von Windheim N, Nogan S, Seim NB, VanKoevering KK. Use of 3-dimensional printing at the point-of-care to manage a complex wound in hemifacial necrotizing fasciitis. 3D Print Med 2023;9(1):4. PMID: 36802228.
- Nyirjesy SC, Yu J, Dharmadhikari S, Liu L, Bergman M, Tan ZH, VanKoevering KK, Chiang T. Successful Early Neovascularization in Composite Tracheal Grafts. Otolaryngol Head Neck Surg 2023;169(4):1035–1040. PMID: 37036314.
- Tan ZH, Liu L, Dharmadhikari S, Shontz KM, Kreber L, Sperber S, Yu J, Byun WY, Nyirjesy SC, Manning A, Reynolds SD, Chiang T. Partial decellularization eliminates immunogenicity in tracheal allografts. Bioeng Transl Med 2023;8(5):e10525. PMID: 37693070.
- Ahmed M, Melaragno LE, Nyirjesy SC, von Windheim N, Fenberg R, Herster R, Sheldon A, Binzel K, Knopp MV, Herderick ED, VanKoevering KK. Higher Computed Tomography (CT) Scan Resolution Improves Accuracy of Patient-specific Mandibular Models When Compared to Cadaveric Gold Standard. J Oral Maxillofac Surg 2023;81(9):1176–1185. PMID: 37315925.
- Nyirjesy SC, McCrary HC, Zhao S, Judd RT, Farlow JL, Seim NB, Ozer E, Agrawal A, Old MO, Rocco JW, Kang SY, Haring CT. National Trends in 30-Day Readmission Following Transoral Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma. JAMA Otolaryngol Head Neck Surg 2024;150(2):133–141. PMID: 38153724.
- Nyirjesy SC, Lewis JH, Hallak D, Conroy S, Moberly AC, Tamati TN. Evaluating Listening Effort in Unilateral, Bimodal, and Bilateral Cochlear Implant Users. Otolaryngol Head Neck Surg 2024;170(4):1147–1157. PMID: 38104319.
- Ahmed M, Garzanich M, Melaragno LE, Nyirjesy S, von Windheim N, Marquardt M, Luttrull M, Quails N, VanKoevering KK. Exploring CT pixel and voxel size effect on anatomic modeling in mandibular reconstruction. 3D Print Med 2024;10(1):21. PMID: 37353456.
- Liu L, Sher AC, Arsuaga-Zorrilla C, Shamim H, Nyirjesy S, Shontz K, Hussein Z, Sussman S, Manning A, Chiang T. Establishing Benchmarks for Airway Replacement: Long-Term Outcomes of Tracheal Autografts in a Large Animal Model. Ann Otol Rhinol Laryngol 2024: 34894241282582. https://doi.org/10.1177/00034894241282582.
- Dattilo LW, de Groot ECM, Nyirjesy S, Karadaghy OA, Noyes E, Spector ME, Richmon JR, Lin DL, Varvares MA, Feng AL. Donor Site Morbidity of the Medial Sural Artery Perforator (MSAP) Free Flap for Head & Neck Reconstruction. Head Neck 2025. https://doi.org/10.1002/hed.28187.
- Nyirjesy SC, de Groot ECM, Richmon JD, Feng AL. Tunneled Facial Artery Myomucosal (t-FAMM) Flap Reconstruction for Early Stage Oral Tongue Squamous Cell Carcinoma: Shorter Operative Times and Earlier Swallowing. Oper Tech Otolaryngol-Head Neck Surg 2025. https://doi:10.1016/j.otot.2025.05.003.
- de Groot ECM, Nyirjesy SC, Faden D, Lin DT, Deschler DG, Feng AL, Richmon JD. Salvage Transoral Robotic Surgery with Submental Flap Reconstruction: Functional and Oncologic Outcomes. Ann Otol Rhinol Laryngol 2025. https://doi.org/10.1177/00034894251347103.
- Nyirjesy SC, de Groot ECM, Richmon JD, Deschler DG. The Submental Island Flap for Reconstruction of Maxillectomy Defects in the Elderly. Laryngoscope Investig Otolaryngol 2025. https://doi.org/10.1002/lio2.70196
- Judd RT, Sethuraman S, Rind F, Zhao S, Nyirjesy SC, Freeman T, Ozer E, Agrawal A, VanKoevering K, Carrau R, Rocco JW, Old MO, Miller LE, Kang SY, Seim NB, Haring CT. Survival Outcomes in Young Nonsmoking–Nondrinking Individuals With Oral Cavity Squamous Cell Carcinoma. Head Neck 2025. https://doi.org/10.1002/hed.28260.
- Nyirjesy SC, Al-Inaya Y, Zhang S, Karadaghy OA, Lin DT, Deschler DG, Feng AL, Varvares MA, Fisch AS, Faden DL, Richmon JD. Incidence of HPV-independent second primary malignancies following treatment of HPV-associated malignancy. Oral Oncology. 2026 Jan 1;172:107790.
- Heller MA, Nyirjesy SC, Balsiger R, Talbot N, VanKoevering KK, Haring CT, Old MO, Kang SY, Seim NB. Modifiable risk factors for oral cavity cancer in non-smokers: A systematic review and meta-analysis. Oral Oncol. 2023 Feb;137:106300. PMID: 36638697
- Nyirjesy SC, Heller M, von Windheim N, Gingras A, Kang SY, Ozer E, Agrawal A, Old MO, Seim NB, Carrau RL, Rocco JW, VanKoevering KK. The role of computer aided design/computer assisted manufacturing (CAD/CAM) and 3-dimensional printing in head and neck oncologic surgery: a review and future directions. Oral Oncol 2022;132:105976. PMID: 35809506.
- Cohn JE, Nyirjesy S, Davis WJ. Repair of a secondary cleft lip deformity with the Abbé flap in a pediatric patient. Ear Nose Throat J 2019;98(5):265-7. PMID: 30935227.
- Nyirjesy S, Osmundson P, Matrka L. Spontaneous regression of recurrent respiratory papillomatosis with HPV vaccination: a case study. J Voice 2022;36(4):587.e21-5. PMID: 32891477.
Article on the Ohio State University Wexner Medical Center website, 2023, “ENT resident Sarah Nyirjesy, MD, designs novel 3D-printed splint to save a patient’s life”
https://wexnermedical.osu.edu/departments/innovations/ent/3d-printed-splint