American Head & Neck Society

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Sandeep Samant

Northwestern Medicine

  • Head and Neck Research
  • Head and Neck Surgeon

676 N St Clair St Arkes Pavilion, #1200
Chicago, IL 60611
United States
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As the chief of head and neck surgery and director of Northwestern multidisciplinary head and neck program, Dr. Sandeep Samant leads the largest Head and Neck Cancer practice in the Chicago region, specializing in complex head and neck surgery and surgical oncology. He has been recognized as Castle Connolly Top Doctor for 15 consecutive years by his peers. He completed fellowship training in head and neck oncologic and skull base surgery in 1996 and has performed over 9000 operations for head and neck cancer.Dr. Samant's clinical and research interests include management of oral, oropharyngeal, laryngeal, nasal, sinus and thyroid cancer. He specializes in minimally invasive surgery utilizing robotic and endoscopic techniques.

https://www.cancer.northwestern.edu/clinical-trials/trials.html

  1. Pahor AL, Samant S. Retropharyngeal myxoma: a case report. J Laryngol Otol. 1994;108(8):690–692.
  2. Robbins KT, Samant S. The role of imaging in the management of clinically N0 neck. Proceedings of the Fourth International Conference on Head and Neck Cancer, Toronto, Canada. 1996:542–547.
  3. Newman LA, Vieira F, Schwiezer V, Samant S, Murry T, Woodson G, et al. Eating and weight changes following chemoradiation therapy for advanced head and neck cancer. Arch Otolaryngol Head Neck Surg. 1998;124(5):589–592.
  4. Samant S, Kumar P, Wan J, Hanchett C, Vieira F, Murry T, et al. Concomitant radiation therapy and targeted cisplatin chemotherapy for the treatment of advanced pyriform sinus carcinoma: disease control and preservation of organ function. Head Neck. 1999;21(7):595–601.
  5. Wani MK, Koseki Y, Yarber RH, Sweatman TW, Ahmed A, Samant S, et al. Rationale for intralesional valrubicin in chemoradiation of squamous cell carcinoma of the head and neck. Laryngoscope. 2000;110(12):2026–2032.
  6. Samant S, Robbins KT, Kumar P, Ma JZ, Vieira F, Hanchett C. Bone or cartilage invasion by advanced head and neck cancer: intra-arterial supradose cisplatin chemotherapy and concomitant radiotherapy for organ preservation. Arch Otolaryngol Head Neck Surg. 2001;127(12):1451–1456.
  7. Staton J, Robbins KT, Newman L, Samant S, Sebelik M, Vieira F. Factors predictive of poor functional outcome after chemoradiation for advanced laryngeal cancer. Otolaryngol Head Neck Surg. 2002;127(1):43–47.
  8. Robbins KT, Samant S. Intra-arterial chemotherapy for advanced head and neck cancer. Proceedings of the 2nd World Congress of International Federations of the Head and Neck Oncologic Societies, Rio de Janeiro. Monduzzi Press, Italy; 2002.
  9. Samant S, Robbins KT. Evolution of neck dissection for improved functional outcome. World J Surg. 2003;27(7):805–810.
  10. Robbins KT, Samant S, Vieira F, Kumar P. Presurgical cytoreduction of oral cancer using intra-arterial cisplatin and limited concomitant radiation therapy (Neo-RADPLAT). Arch Otolaryngol Head Neck Surg. 2004;130:28–32.
  11. Robbins KT, Dowek I, Samant S, Vieira F, Kumar P. Factors predictive of local disease control after intra-arterial concomitant chemoradiation (RADPLAT). Laryngoscope. 2004;114(3):411–417.
  12. Naidu SI, Vieira F, Samant S. Selective versus nonselective intra-arterial chemoradiation for tonsil cancer. Otolaryngol Head Neck Surg. 2005;133(6):882–887.
  13. Samant S, Robbins KT, Vang M, Wan J, Robertson J. Intra-arterial cisplatin and concomitant radiation followed by surgery for advanced paranasal sinus cancer. Arch Otolaryngol Head Neck Surg. 2004;130(8):948–955.
  14. Ahmed A, Samant S, Vieira F. Gastrostomy tube placement for patients undergoing chemoradiation for advanced head and neck cancer. Laryngoscope. 2005;115(1):44–47.
  15. Micheal M, Samant S, Robertson J. The treatment of advanced sinonasal malignancies with preoperative intra-arterial cisplatin and concurrent radiation. J Neurooncol. 2005;72(1):67–75.
  16. Forastiere AA, et al. Head and neck cancers. J Natl Compr Canc Netw. 2005;3(3):316–391.
  17. Robbins KT, Doweck I, Samant S, Vieira F. Effectiveness of superselective and selective neck dissection for advanced nodal metastases after chemoradiation. Arch Otolaryngol Head Neck Surg. 2005;131(11):965–969.
  18. Forastiere AA, Ang K, Brizel D, et al. [incl. Samant S]. Head and neck cancers. J Natl Compr Canc Netw. 2005;3(3):316–391.
  19. Stumpe M, Chandra R, Yunus F, Samant S. Incidence and risk factors of bisphosphonate-associated osteonecrosis of the jaws. Head Neck. 2009;31(2):202–206.
  20. Samant S, Kruger E. Cancer of the paranasal sinuses: an update. Curr Oncol Rep. 2007;9:147–151.
  21. Doweck I, Robbins KT, Samant S, Vieira F. Intra-arterial chemoradiation for T3–4 oral cavity cancer: treatment outcomes in comparison to oropharyngeal and hypopharyngeal carcinoma. World J Surg Oncol. 2008;6:2.
  22. NCCN, Forastiere AA, Ang KK, et al. [incl. Samant S]. Head and neck cancers. J Natl Compr Canc Netw. 2008;6(7):646–695.
  23. Gorman M, Ahmed KA, Pallera A, Samant S. Granulocytic sarcoma of the nasal cavity: a case report. ENT Journal. 2009;88(11):1210–1212.
  24. Samant S, van den Brekel MW, Kies MS, Wan J, Robbins KT, Rosenthal DI, Rasch C, Weber RS. Concurrent chemoradiation for advanced unresectable adenoid cystic carcinoma: a 3-institution experience. Head Neck. 2012;34(9):1263–1268.
  25. Watkins J, Williams G, Mascioli A, Wan J, Samant S. Shoulder function in patients undergoing selective neck dissection with or without radiation and chemotherapy. Head Neck. 2011;33(5):615–619.
  26. Shires C, Stocks R, Thompson J, Sebelik M, Samant S. Alveolar soft part sarcoma of the thyroid gland in a child. Int J Pediatr Otorhinolaryngol Extra. 2010.
  27. Rao SK, Pavicevic Z, Du Z, Kim J, Fan M, Jiao Y, Rosebush M, Samant S, Gu W, Pfeffer LM, Nosrat CM. Pro-inflammatory genes as biomarkers and therapeutic targets in oral squamous cell carcinoma. J Biol Chem. 2010.
  28. Pfister DG, Ang KK, Brizel DM, et al. [incl. Samant S]. Head and neck cancers. J Natl Compr Canc Netw. 2011;9:596–650.
  29. NCCN Clinical Practice Guidelines in Oncology: Head and Neck Cancers. Pfister DG, Ang KK, et al. [incl. Samant S]. J Natl Compr Canc Netw. 2011;9(6):596–650.
  30. Rosebush MS, Rao SK, Samant S, Gu W, Handorf CR, Pfeffer LM, Nosrat CA. Oral cancer: enduring characteristics and emerging trends. J Tenn Dent Assoc. 2011;91(2):24–27.
  31. Weir A, Ganti AK, DeShazo M, Samant S, Hurria A. Management of squamous cell carcinoma in the elderly: review and recommendations. J Geriatr Oncol. 2012.
  32. Pfister DG, Ang KK, Brizel DM, et al. [incl. Samant S]. Mucosal melanoma of the head and neck. J Natl Compr Canc Netw. 2012;10(3):320–338.
  33. Konofaos P, Hammond S, Ver Halen J, Samant S. Reconstructive techniques in transoral robotic surgery for head and neck cancer: a North American survey. Plast Reconstr Surg. 2013;131(2):188e–197e.
  34. Samant S. Sentinel node biopsy as an alternative to elective neck dissection for staging of early oral carcinoma. Head Neck. 2014;36(2):241–246.
  35. Pfister DG, Ang KK, Brizel DM, et al. [incl. Samant S]. Head and neck cancers, Version 2.2013. J Natl Compr Canc Netw. 2013;11:917–923.
  36. Cohen EEW, Karrison T, Kocherginsky M, Mueller J, et al. [incl. Samant S]. Phase III randomized trial of docetaxel-based induction chemotherapy in patients with N2/N3 locally advanced head and neck cancer. J Clin Oncol. 2014;32(25):2735–2743.
  37. Frederico S, Gilpin D, Samant S, Billups C, Spunt S. Clinical features and outcomes of young patients with head and neck non-rhabdomyosarcoma soft tissue sarcomas. Head Neck. 2014.
  38. Wood J, Ver Halen J, Samant S. Upper extremity deep vein thrombosis and pulmonary embolus after radial forearm free flap: a case report and literature review. J Plast Surg. 2014.
  39. Kim BD, Lim S, Wood J, Samant S, Ver Halen JP, Kim JYS. Predictors of adverse events after parotidectomy: a review of 2919 cases. Ann Otol Rhinol Laryngol. 2015;124(1):35–44.
  40. Jain U, Antony AK, Somerville J, Saha S, Samant S, Ver Halen JP, Kim JYS. Predictors of adverse events after neck dissection: an analysis of the 2006–2011 NSQIP datasets. Ear Nose Throat J. 2017;96(2):E37–E45.
  41. Shires C, Samant S. Multiple plasma cell granulomas of the larynx in a young man. Ear Nose Throat J. 2014;93(3):E28–31.
  42. Khavanin N, Mlodinow A, Antony AK, Kim JYS, Samant S, Ver Halen JP. Assessing safety and outcomes in outpatient versus inpatient thyroidectomy using the NSQIP: a propensity score matched analysis of 16,370 patients. Ann Surg Oncol. 2015;22(2):429–436.
  43. Khavanin N, Mlodinow A, Kim JYS, Ver Halen JP, Samant S. Predictors of 30-day readmission after outpatient thyroidectomy: an analysis of the 2011 NSQIP data set. Am J Otolaryngol. 2014.
  44. Smith A, Peterson D, Ver Halen JP, Samant S. Pediatric mandibular reconstruction following resection of oral squamous cell carcinoma: a case report. Am J Otolaryngol. 2014;35(6):826–828.
  45. Mlodinow A, Khavanin N, Shires C, Samant S, Ver Halen JP, Kim J. Predictors of adverse events after total laryngectomy: an analysis of the 2005–2011 NSQIP datasets. J Otolaryngol Adv.
  46. Surgical risk after unilateral lobectomy versus total thyroidectomy: a review of 47,434 patients. [incl. Samant S]. J Clin Oncol. 2014;32(25):2735–2743.
  47. Wood J, Ver Halen J, Samant S, Florendo N. Radiation-induced sarcoma masquerading as osteoradionecrosis: case report and literature review. J Laryngol Otol. 2015;129(3):279–282.
  48. Bishop M, Somerville JM, Bahrami A, et al. [incl. Samant S]. Mesenchymal chondrosarcoma in children and young adults: a single institution retrospective review. Sarcoma. 2015;2015:608279.
  49. Somerville J, Ver Halen J, Samant S. Oropharyngeal contamination predisposes to complications after neck dissection: an analysis of 9462 patients. Otolaryngol Head Neck Surg. 2015;153(1):71–78.
  50. Linga VG, Moskovitz J, Ganguly D, et al. [incl. Samant S], Pfeffer LM. Dysregulated signaling pathways in human papillomavirus positive oropharyngeal cancers. J Stem Cell Res Med. 2016;1(1):1–7.
  51. Cramer JD, Patel UA, Samant S, Smith SS. Postoperative complications in elderly patients undergoing head and neck surgery: opportunities for quality improvement. Otolaryngol Head Neck Surg. 2016;154(3):518–526.
  52. Cramer JD, Patel UA, Samant S, Smith SS. Liver disease in patients undergoing head and neck surgery: incidence and risk for postoperative complications. Laryngoscope. 2017;127(1):102–109.
  53. Cramer JD, Samant S, Greenbaum E, Patel UA. Free tissue transfer to the upper aerodigestive tract with or without elective tracheostomy. JAMA Otolaryngol Head Neck Surg. 2016;142(12):1177–1183.
  54. Cramer JD, Patel UA, Maas MB, Samant S, Smith SS. Is neck dissection associated with an increased risk of postoperative stroke? Otolaryngol Head Neck Surg. 2017.
  55. Cramer JD, Patel UA, Samant S, Shintani Smith S. Discharge destination after head and neck surgery: predictors of discharge to postacute care. Otolaryngol Head Neck Surg. 2016;155(6):997–1004.
  56. Poropatich K, Hernandez D, Fontanarosa J, et al. [incl. Samant S]. Peritumoral cuffing by T cell tumor-infiltrating lymphocytes distinguishes HPV-related oropharyngeal squamous cell carcinoma from oral cavity squamous cell carcinoma. J Oral Pathol Med. 2017.
  57. Patel RA, Lock D, Kim T, Samant S, Chandler JP, Mittal BB, Kruser TJ. Single fraction stereotactic radiosurgery for retreatment of skull base recurrent head and neck malignancies. Cureus. 2017;9(5):e1206.
  58. Poropatich K, Fontanarosa J, Samant S, Sosman JA, Zhang B. Cancer immunotherapies: are they as effective in the elderly? Drugs Aging. 2017.
  59. Alexiev BA, Jennings LJ, Samant S, Rao S. Oncocytic papillary cystadenoma with prominent mucinous differentiation of parotid gland: a case report. Pathol Res Pract. 2017;213(10):1310–1314.
  60. Poropatich K, Fontanarosa J, Swaminathan S, et al. [incl. Samant S], Zhang B. Comprehensive T-cell immunophenotyping and next-generation sequencing of HPV-positive and HPV-negative head and neck squamous cell carcinomas. J Pathol. 2017;243(3):354–365.
  61. Cramer JD, Speedy SE, Ferris RL, Rademaker AW, Patel UA, Samant S. National evaluation of multidisciplinary quality metrics for head and neck cancer. Cancer. 2017;123(22):4372–4381.
  62. Cramer JD, Hicks KE, Rademaker AW, Patel UA, Samant S. Validation of the eighth edition AJCC staging system for HPV-associated oropharyngeal cancer. Head Neck. 2018;40(3):457–466.
  63. Cramer JD, Dilger AE, Schneider A, Smith SS, Samant S, Patel UA. Risk of venous thromboembolism among otolaryngology patients vs general surgery and plastic surgery patients. JAMA Otolaryngol Head Neck Surg. 2017.
  64. Cramer JD, Reddy A, Ferris RL, Duvvuri U, Samant S. Comparison of the seventh and eighth edition AJCC oral cavity staging systems. Laryngoscope. 2018;128(10):2351–2360.
  65. Cramer JD, Sridharan S, Ferris RL, Duvvuri U, Samant S. Sentinel lymph node biopsy versus elective neck dissection for stage I to II oral cavity cancer. Laryngoscope. 2019;129(1):162–169.
  66. Cramer JD, Samant S, Heron DE, Ferris RL, Kim S. Impact of postoperative radiation therapy for deeply invasive oral cavity cancer upstaged to stage III. Head Neck. 2019.
  67. Alexiev BA, Behdad A, Lu X, Cheng E, Samant S. High-risk HPV-mediated adenocarcinoma of palatine tonsil. Pathol Res Pract. 2020;152924.
  68. Owen JL, Kibbi N, Worley B, et al. [incl. Samant S]. Sebaceous carcinoma: evidence-based clinical practice guidelines. Lancet Oncol. 2019;20(12):e699–714.
  69. Alexiev BA, Behdad A, Lu X, Cheng E, Samant S. High-risk human papillomavirus-mediated adenocarcinoma of palatine tonsil. Pathol Res Pract. 2020;152924.
  70. Poropatich K, Dominguez D, Chan WC, et al. [incl. Samant S], Zhang B. OX40+ plasmacytoid dendritic cells in the tumor microenvironment promote antitumor immunity. J Clin Invest. 2020.
  71. Kono T, Hoover P, Poropatich K, et al. [incl. Samant S], Laimins LA. Activation of DNA damage repair factors in HPV positive oropharyngeal cancers. Virology. 2020.
  72. Jager L, Felicelli C, Alexiev B, Samant S, Johnson DN. Anaplasia and multinucleation in metastases of oropharyngeal squamous cell carcinoma is associated with poorer outcomes. J Am Soc Cytopathol. 2022;11(4):201–209.
  73. Wernick BD, Furlough CL, Patel U, Samant S, Hoel AW, Rodriguez HE, Tomita TT, Eskandari MK. Contemporary management of carotid body tumors in a Midwestern academic center. Surgery. 2021;169(3):700–704.
  74. Mehta MP, Prince R, Butt Z, Maxwell BE, Carnes BN, Patel UA, Stepan KO, Mittal BB, Samant S. Evaluating dysphagia and xerostomia outcomes following transoral robotic surgery for patients with oropharyngeal cancer. Head Neck. 2021;43(12):3955–3965.
  75. Issa N, Liddy WE, Samant S, Conley DB, Kern RC, Hungness ES, Barsuk JH. Emergency cricothyrotomy during the COVID-19 pandemic: how to suppress aerosolization. Trauma Surg Acute Care Open. 2020;5(1):e000542.
  76. Suresh K, Shah PV, Coates S, Alexiev BA, Samant S. In situ hybridization for high risk HPV E6/E7 mRNA in oropharyngeal squamous cell carcinoma. Am J Otolaryngol. 2021;42(1):102782.
  77. Issa N, Liddy WE, Samant S, Conley DB, Kern RC, Hungness ES, Cohen ER, Barsuk JH. Effectiveness of a simulation-based mastery learning to train clinicians on a novel cricothyrotomy procedure at an academic medical centre during a pandemic. BMJ Open. 2021;11(11):e054746.
  78. Shaunfield S, Yount SE, Boyken L, Agulnik M, Samant S, Cella D. Optimizing brief, focused assessment of priority symptoms and concerns in recurrent and/or metastatic SCCHN: content validation of the FHNSI-10. Health Sci Rep. 2021;4(4):e401.
  79. Asthana S, Park AC, Talwar A, et al. [incl. Samant S]. Association of neighborhood-level area deprivation with demographics and outcomes in oropharyngeal squamous cell carcinoma. OTO Open. 2024;8(4):e70057.
  80. Fei-Zhang DJ, Park AC, Chelius DC, et al. [incl. Samant S]. Influence of social vulnerability in treatment and prognosis of squamous cell carcinoma of the tongue. Otolaryngol Head Neck Surg. 2024;170(5):1338–1348.
  81. Park AC, Asthana S, Talwar A, et al. [incl. Samant S]. Statewide Social Vulnerability Index (SVI) in HPV-associated oropharyngeal squamous cell carcinoma. Am J Clin Oncol. 2025;48(11):540–547.
  82. Park AC, Fehrenbach MP, Davis RJ, et al. [incl. Samant S]. Social Vulnerability Index as a tool to evaluate the distribution of head and neck oncology surgeons. Laryngoscope. 2025;135(9):3178–3185.
  83. Park AC, Fehrenbach MP, Wang LW, et al. [incl. Samant S]. Postoperative opioid receipt after parotidectomy and associations with persistent opioid use disorder. Otolaryngol Head Neck Surg. 2025;173(5):1131–1137.
  84. Park AC, Wang L, Fehrenbach MP, et al. [incl. Samant S]. Non-tobacco nicotine use and complications in free flap repair in head and neck cancer. Laryngoscope. 2025;135(10):3630–3638.
  85. Talwar A, Asthana S, Silva-Nash J, et al. [incl. Samant S]. Outcome predictors of hardware complications in head and neck free flap reconstruction. Am J Clin Oncol. 2025;48(6):319–324.
  86. Talwar A, Gordon AJ, Bewley AF, et al. [incl. Samant S]. Distribution of the head and neck surgical oncology workforce in the United States. Head Neck. 2022;44(11):2537–2544.
  87. Talwar A, Kim S, Yu S, Samant S, Tozan Y, Givi B. Private payer-negotiated rates for FDA-approved head and neck cancer immunotherapy and chemotherapy agents. Otolaryngol Head Neck Surg. 2023;169(4):954–961.
  88. Weiland AC, Samant S, Clain AE, Martin-Harris B. Short- and long-term swallowing outcomes in head and neck cancer patients receiving TORS and adjuvant therapy. Head Neck. 2025;47(5):1345–1354.