Practice Contact Information
Johns Hopkins University
601 North Caroline Street
601 North Caroline Street
Baltimore
Maryland
21231
United States
Phone: 4109552256
Email: [email protected]
Web Site: https://www.hopkinsmedicine.org/profiles/results/directory/profile/10004480/peter-vosler
Areas of surgical specialization in Head and Neck Surgery
Endocrine Surgery, Head and Neck Surgeon, Reconstructive Head & Neck Surgery
Biography/Statement
Dr. Vosler received his medical degree and Ph.D. from the University of Pittsburgh. He completed his otolaryngology-head and neck surgery residency at the University of Pittsburgh Medical Center, and his fellowship in head and neck surgical oncology, robotic surgery, endocrine surgery, and microvascular reconstruction from the University of Toronto. Dr. Vosler is also an Army veteran serving one tour of duty in Iraq.
Dr. Vosler specializes in the treatment of benign and malignant tumors of the head and neck. As a clinician, Dr. Vosler is an expert in malignant tumors of the tongue, oropharynx, throat, salivary glands, and thyroid. As a researcher, his interests are focused on implementation of technology in the advancement of surgical practice and improvements in the diagnosis and treatment of depression in head and neck cancer patients. Patients with head and neck cancer have a high incidence of depression, and depression has been shown to negatively impact quality of life and overall survival of head and neck cancer patients despite successful cancer treatment. Dr. Vosler’s research focuses on early diagnosis and treatment of depression in patients with head and neck cancer.
Innovations being pursued by Dr. Vosler:
-Use of optical coherence tomography to assess surgical margins in tongue cancer. Optical coherence tomography, or OCT, is a high-resolution imaging technique that allows for microscopic evaluation of tissue to distinguish between normal tissue and cancer.
Clinical Trials
Bibliography
Gourin, C.G., Vosler, P.S., Mandal, R., Pitman, K.T., Fakhry, C., Eisele, D.W., and Frick, K.D. & Austin J.M., (2019). Association between hospital market concentration and costs of laryngectomy. JAMA Otolaryngol Head Neck Surg, 145(10), 939-947. PMID: 31465102.
Vosler, P.S., Orsini, M., Enepekides, D.J., & Higgins, K.M. (2018). Predicting complications of major head and neck oncological surgery: an evaluation of the ACS NSQIOP surgical risk calculator. J Otolaryngol Head Neck Surg, 47(1), 21. PMID: 29566750.
Noel, C.W., Vosler, P.S., Hong, M., Orsini, M., Enepekides, D., & Higgins, K. (2018). Motor and sensory morbidity associated with the anterolateral thigh perforator free flap. Laryngoscope, 128(5), 1057-61. PMID: 29105774.
Vosler, P.S., Kass, J.I., Wang, E.W. and Snyderman, C.H. (2016). Successful implementation of a clinical care pathway for management of epistaxis at a tertiary-care center. Otolaryngol Head Neck Surg, 155(5), 879-885. PMID: 27352889.
Davis, K.S., Vosler, P.S., Yu, J., and Wang, E.W. (2016). Intraoperative image guidance improves outcomes in complex orbital reconstruction by novice surgeons. J Oral Maxillofac Surg, 74(7), 1420-1425. PMID: 27019413.
Vosler, P.S., Ferguson, B.J., Contreras, J.I., Wang, E.W., Schaitkin, B.M., and Lee, S. (2014). Clinical and pathologic characteristics of intranasal abuse of combined opioid-acetaminophen medications. Int Forum Allergy Rhinol, 4(10), 839-44. PMID: 25137346.
Zhang, L., Zhang, F., Weng, Z., Brown, B.N., Yan, H., Ma, X.M., Vosler, P.S., Badylak, S.F., Dixon, C.E., Cui, X.T., & Chen, J. (2013). Effect of an inductive hydrogel composed of urinary bladder matrix upon functional recovery following traumatic brain injury. Tissue Eng Part A, 19(17-18), 1909-18. PMID: 23596981.
Shi, H., Sun, B.L., Zhang, L., Lu, S., Zhang, P., Wang, H., Yu, Q., Stetler, R.A., Vosler, P.S., Chen, J., & Gao, Y. (2013). miR-15b suppression of Bcl-2 contributes to cerebral ischemic injury and is reversed by sevoflurane preconditioning. CNS Neurol Disord Drug Targets, 12(3), 381-91. PMID: 23469855.
Zhang, M., Wang, H., Zhao, J., Chen, C., Leak, R.K., Xu, Y., Vosler, P., Chen, J., Gao, Y., & Zhang, F. (2013). Drug-induced hypothermia in stroke models: does it always protect? CNS Neurol Disord Drug Targets, 12(3), 371-80. PMID: 23469851
Yuan, F., Wang, Y., Guan,. Y., Ren, Y, Lu, H., Xiao, T., Xie, H., Vosler, P.S., Chen, J. & Yang, G. (2013). Real-time imaging of mouse lenticulostriate artery following brain ischemia. Frontiers in Biosciences (Elite Ed.), 5, 517-24. PMID: 23277007.
Zhang, P., Zhang, Q., Pu, H., Wu, Y., Bai, Y., Vosler, P.S., Chen, J., Shi, H., Gao, Y., & Hu, Y. (2012). Very early-initiated physical rehabilitation protects against ischemic brain injury. Frontiers in Biosciences (Elite Ed.), 4, 476-89. PMID: 22652654.
Stetler, R.A., Gao, Y., Zhang, L., Weng, Z., Zhang, F., Hu, X., Wang, S., Vosler, P., Cao, G., Sun, D., Graham, S.H., & Chen, J. (2012). Phosphorylation of HSP27 by protein kinase D is essential for mediating neuroprotection against ischemic neuronal injury. Journal of Neuroscience, 32(8), 2667-89. PMID: 22357851.
Gan, Y., Ji, X., Hu, X., Luo, Y., Zhang, L., Li, P., Liu, X., Vosler, P., Gao, Y., Stetler, R.A., & Chen, J. (2012). Transgenic overexpression of peroxiredoxin-2 attenuates ischemic neuronal injury via suppression of a redox-sensitive pro-death signaling pathway. Antioxid Redox Signal, 17(5), 719-32. PMID: 22356734.
Vosler, P.S., Zhang, F., Brennan, C.S., Yanagiya, A., Cao, G., Wang, S., Morley, S.J., Sonenberg, N. & Chen, J. (2011). Establishment of a causal link between protein synthesis inhibition and neuronal death via calpain-mediated degradation of eIF4G. Proceedings of the National Academy of Sciences, 108(44), 18102-7. PMID: 22006312.
Zhang, F., Wang, S., Gan, L., Vosler, P.S., Zigmond, M.J. & Chen, J. (2011). Protective effects and mechanisms of sirtuins in the nervous system. Progress in Neurobiology, 95(3), 373-95. PMID: 21930182.
Wang, G., Jiang, Z., Li, Y., Li, X., Shi, H., Gao, Y., Vosler, P.S., & Chen, J. (2011). Free-radical scavenger edaravone treatment confers neuroprotection against traumatic brain injury in rats. J Neurotrauma, 28(10), 123-34. PMID: 21732763.
Stetler, R.A., Gao, Y., Zukin, R.S., Vosler, P.S., Zhang, L., Zhang, F., Cao, G., Bennett, M.V.L. and Chen, J. (2010). Apurinic/apyrimidinic endonuclease APE1 is required for PACAP-induced neuroprotection against global cerebral ischemia. PNAS, 107(7) 3204-9. PMID: 20133634.
Gao Y., Cao G., Zhang W., Hu, X, Stetler, R.A. Vosler P. and Chen J. (2010). Neuroprotection against hypoxic-ischemic brain injury by inhibiting the apoptotic protease activating factor-1 pathway. Stroke, 41(1) 166-72. PMID: 19910549.
Vosler, P.S., Graham, S.H., Wechsler, L. and Chen J. (2009). Mitochondrial targets for stroke: Focusing basic science research toward development of clinically translatable therapeutics. Stroke, 40(9), 3149-55. Review. PMID: 19478227.
Vosler, P.S., Sun, D., Wang, S., Gao, Y., Kitner, D.B., Signore, A.P., Cao, G. and Chen, J. (2009). Calcium dysregulation induces apoptosis-inducing factor release: Cross-talk between PARP-1 and calpain-signaling pathways. Experimental Neurology, 218(2), 213-220. PMID: 19427306.
Vosler, P.S. and Chen, J. (2009). Potential molecular targets for translational stroke research. Stroke, 40(3 Suppl), S119-120. Review. PMID: 19064800.
Stetler, R.A., Cao, G, Gao, Y, Zhang, F. Wang, S., Weng, Z, Vosler, P., Zhang, L., Signore, A., Graham, S. and Chen, J. (2008). Hsp27 protects against ischemic brain injury via attenuation of a novel stress-response cascade upstream of mitochondrial death signaling. Journal of Neuroscience, 28(49), 13038-55. PMID: 19052195.
Vosler, P.S., Brennan, C.S. and Chen, J. (2008). Calpain-mediated signaling mechanisms in neuronal injury and neurodegeneration. Molecular Neurobiology, 38(1), 78-100. Review. PMID: 18686046.
Wang, S., Xing, Z., Vosler, P.S., Wang, H., Signore, A., Stetler, R.A., Gao, Y., and Chen, J. (2008). Cellular NAD replenishment confers marked neuroprotection against oxygen-glucose deprivation: role of enhanced DNA repair. Stroke, 39(9), 2587-2595. PMID: 18617666.
Vosler, P.S., Logue, E.S., Repine, M.J. & Callaway, C.W. (2005). Delayed hypothermia preferentially increases expression of brain-derived neurotrophic factor exon III in rat hippocampus after asphyxial cardiac arrest. Brain Research Molecular Brain Research, 135(1-2), 21-29. PMID: 15857665.
Castner, S.A., Vosler, P.S. & Goldman-Rakic, P.S. (2005). Amphetamine sensitization impairs cognition and reduces dopamine turnover in primate prefrontal cortex. Biological Psychiatry, 57(7), 743-751. PMID: 15820231.
Vosler, P.S., Bombace, J.C., & Kosten, T.A. (2001). A discriminative two-lever test of dizocilpine’s ability to reinstate ethanol-seeking behavior. Life Sciences, 69(5), 591-598. PMID: 11510953.