American Head & Neck Society

Advancing Education, Research, and Quality of Care for the Head and Neck oncology patient.

Published on by Mirabelle Sajisevi

Mirabelle Sajisevi – Burlington, Vermont

Practice Contact Information

University of Vermont Medical Center
111 Colchester Ave

Burlington
Vermont
05401
United States

Phone: 802-847-4535
Email:
Web Site: https://www.uvmhealth.org/medcenter/provider/mirabelle-sajisevi-md

Areas of surgical specialization in Head and Neck Surgery

Endocrine Surgery, Head and Neck Surgeon, Reconstructive Head & Neck Surgery

Biography/Statement

Dr. Mirabelle Sajisevi is an otolaryngologist at the University of Vermont Medical Center and assistant professor at the Larner College of Medicine at UVM in Burlington, VT. She completed residency at Duke University Medical Center and fellowship training at the Mayo Clinic in Rochester, MN.  Her practice focuses on head and neck cancer treatment and endocrine surgery. She is trained in transoral robotic surgery and microvascular reconstruction.

Clinical Trials

Bibliography

Carpenter, D.J., Sajisevi M., Chapurin, N., Brown, C.S., Cheng, T., Palmer, G.M., Stevenson, D.S., Rao, C.L., Hall, R.P., Woodard, C.R. Noninvasive optical spectroscopy for identification of non-melanoma skin cancer: Pilot study. Lasers Surg Med. 2018 Mar:50(3): 246-252

Choi, K., Cheng, T., Cobb, M., Sajisevi, M., Gonzalez, L.F., Ryan, M. Recurrent post-tonsillectomy bleeding due to an iatrogenic facial artery pseudoaneurysm. Acta Oto-Laryngologica Case Reports. 2017; 2(1): 103-106. DOI: 10.1080/23772484.2017.1330122

Sajisevi, M., Schulz, K., Cyr, D., Wojdyla, D., Rosenfeld, R., Tucci, D., Witsell, D. Nonadherence to guideline recommendations for tympanostomy tube insertion in children based on mega-database claims analysis. Otolaryngol Head Neck Surg. 2016 Sep 13. pii: 0194599816669499.

Choi, K., Sajisevi, M., McClennen, J., Kaylie, D. Image guided placement of osseointegrated implants for challenging auricular, orbital and rhinectomy defects. Ann Otol Rhinol Laryngol. 2016 Oct;125(10):801-7.

Sajisevi, M., Wilken, R., Lee, W. The role of professional identity formation in balancing residency service versus education needs. Journal of graduate medical education. 2016 May;8(2):154-5

Sajisevi, M., Hoang, J., Eapen, R., Jang, D. Nasopharyngeal masses arising from embryologic remnants of the clivus: a case series. J Neurol Surg Rep. 2015 Nov; 76(2): e253–e257

Choi, K., Sajisevi, M., Kaylie, D. Incidence of Retrocochlear Pathology Found on MRI in Patients with Non-Pulsatile Tinnitus. Otol Neurotol. 2015 Dec;36(10):1730-4.

Sajisevi, M., Rigual, N., Bellnier, D., Seshadri, M. Image-guided Interstitial Photodynamic Therapy for Squamous Cell Carcinomas: Preclinical investigation. Journal of Oral and Maxillofacial Surgery, Medicine and Pathology. 2015 Mar;27(2): 159-165.

Frank-Ito, D., Sajisevi, M., Solares, A., Jang, D. Modeling alterations in sinonasal physiology following skull base surgery. Am J Rhinol Allergy. 2015 29(2):145–150

Sajisevi, M., Cohen S., Raynor, E. Pedatrician approach to dypshonia. Int J Pediatr Otorhinolaryngol. 2014 Aug;78(8):1365-75

Sajisevi, M., Vess, G., Witsell, D. Otolaryngologic Symptoms in a Patient with Spontaneous Intracranial Hypotension: A Case Report. Otolaryngology-Head and Neck Surgery. 2014 Apr 4;151(2):367-368

Sajisevi, M., Kaylie, D. What is the Role of Imaging in Tinnitus? Laryngoscope. 2014 Mar;124(3):583-4.

Published on by Jorge Pinho

JORGE PINHO – Recife, Pernambuco

Practice Contact Information

HOSPITAL MEMORIAL S. JOSE
56 Rua Tenente Antônio João
Graças
Recife
Pernambuco
52011-130
Brazil

Phone: +55819.9971-4448
Email: [email protected]
Web Site:

Areas of surgical specialization in Head and Neck Surgery

Endocrine Surgery, Head and Neck Surgeon

Biography/Statement

Head and Neck Surgeon

Clinical Trials

Bibliography

Published on by Nadia Mohyuddin

Nadia Mohyuddin – Houston, TX

Practice Contact Information

Houston Methodist Hospital
6550 Fannin Street
Smith Tower, Suite 1723
Houston
TX
77030
United States

Phone: 713-441-1368
Email: [email protected]
Web Site: https://www.houstonmethodist.org/doctor/nadia-mohyuddin/

Areas of surgical specialization in Head and Neck Surgery

Endocrine Surgery, Head and Neck Surgeon

Biography/Statement

Undergraduate & Medical School: University of Missouri-Kansas City Combined BA/MD Program 1997-2003 (Degrees: Biology & Chemistry, Honors with Distinction)

Internship: General Surgery, University of Illinois-Chicago 2003-2004

Residency: Otolaryngology/Head & Neck Surgery, University of Illinois-Chicago 2004-2008

Fellowship: Head and Neck Surgical Oncology & Microvascular Reconstruction, Medical University of South Carolina 2008-2009

Assistant Professor, Bobby R. Alford Department of Otolaryngology/Head and Neck Surgery, Baylor College of Medicine 2009-2018

Faculty, Houston Methodist Hospital 2018-present

Clinical Trials

Bibliography

Published on by Mark Swanson

Mark Swanson – Los Angeles, California

Practice Contact Information

University of Southern California – Keck Medical Center
1450 San Pablo Street

Los Angeles
California
90033
United States

Phone: 323-442-5790
Email:
Web Site: https://keck.usc.edu/otolaryngology/faculty/Mark-Swanson/

Areas of surgical specialization in Head and Neck Surgery

Endocrine Surgery, Head and Neck Research, Head and Neck Surgeon, Reconstructive Head & Neck Surgery

Biography/Statement

Mark Swanson, MD is a fellowship trained head and neck surgeon. After completing medical school at the Ohio State University, he entered a residency in Otolaryngology at University of Southern California. He continued his training with a fellowship in cancer and reconstructive surgery at the University of Miami, and returned to USC to join the faculty at Keck Medical Center. His expertise is in treatment of benign and malignant tumors of the mouth, throat, salivary glands, neck, and thyroid gland. He utilizes advanced robotic, organ preservation, and microvascular reconstructive techniques to maximize quality of life after treatment.

Dr. Swanson works in a multi-disciplinary team including surgeons, radiation oncologists, medical oncologists, and speech/swallow therapists to provide complete care for head and neck diseases.

In addition to treating patients, Dr. Swanson has a research interest in oncologic and quality of life outcomes in head and neck cancers. He focuses on swallowing and voice outcomes after cancer treatments, and is working to provide optimal cancer outcomes while preserving unaffected tissues.

Clinical Trials

Head and neck squamous cell cancer related trials

Bibliography

Bertelsen C, Swanson MS, et al. Contrast-Enhanced Ultrasound with Perflubutane for Sentinel Lymph Node Mapping in Cutaneous Melanoma: A Pilot Study. Laryngoscope – In Press

 Swanson MS, Low G, Sinha UK, Kokot N. Transoral surgery vs intensity-modulated radiotherapy for early supraglottic cancer: a systematic review. Current opinion in otolaryngology & head and neck surgery. April 2017, 25 (2):133-141. [PMID 28106658]

 Swanson MS, Kokot N, Sinha UK. The Role of HPV in Head and Neck Cancer Stem Cell Formation and Tumorigenesis. Cancers. 2016; Feb 19;8(2): 24. [PMID 2907349]

Ouyoung, L.M., M.S. Swanson, B.C. Villegas, et al., ABCLOVE: Voice therapy outcomes for patients with head and neck cancer. Head Neck, 2016. 38 Suppl 1: p. E1810-3. [PMID 26689974]

Swanson MS, Hudson R, Bhandari N, Sinha UK, Maceri DR, Kokot N. Use of Octreotide for the Management of Chyle Fistula Following Neck Dissection. JAMA Otolaryngol Head Neck Surg. 2015 Aug;141(8):723-7. [PMID 26135979]

 Swanson MS, Sinha UK. Rationale for combined blockade of PD-1 and CTLA-4 in Advanced Head and Neck Squamous Cell Cancer – Review of Current Data. Oral Oncology. 2015 Jan; 51(1):12-15. [PMID 25459157]

 Swanson MS, Brown, TN. Laryngotracheal giant cell tumor: case report and literature review. Case reports in Clinical Pathology. 2015; 2(2).  http://dx.doi.org/10.5430/crcp.v2n2p12 [DOI: 10.5430/crcp.v2n2p12]

 Swanson MS, Sinha UK. Diagnosis and Management of Merkel Cell Carcinoma of the Head and Neck: Current Trends and Controversies. Cancers. 2014; 6(3):1256-1266.  [PMID 24978433]

Radhakrishnan V, Swanson MS, Sinha UK. Monoclonal Antibodies as Treatment Modalities in Head and Neck Cancers. AIMS Medical Science, 2015, 2(4): 347-359. [DOI: 10.3934/medsci.2015.4.347]

Published on by William Spanos

William Spanos – Sioux Falls, South Dakota

Practice Contact Information

Sanford Health\Sanford Research, University of South Dakota Department of Surgery
1310 West 22nd Street, Sioux Falls, SD, USA

Sioux Falls
South Dakota
57105
United States

Phone: 605-328-8200
Email: [email protected]
Web Site: https://www.sanfordhealth.org/sioux-falls/services/head-neck-cancer/team

Areas of surgical specialization in Head and Neck Surgery

Endocrine Surgery, Head and Neck Research, Head and Neck Surgeon, Reconstructive Head & Neck Surgery

Biography/Statement

My academic and medical training background includes a strong track record of cancer focused research.  My laboratory focuses on the interaction between the immune system and the cancer cells in human papillomavirus driven head and neck cancers.  I also have an active medical practice caring for and treating head and neck cancer patients.  The failure of treatment in some patients and the morbidity associated with treatment motivate me to search for an improved molecular understanding of head and neck cancer through research.  Current treatment for recurrent metastatic head and neck cancer is limited in efficacy with significant side effects.  My recent research is focused on the interaction of the cancer cell, in the context of chemotherapy treatment, with the immune system and surrounding extracellular environment.  I hope to find ways to augment and modulate that interaction to improve response to treatment and to find less toxic therapy options.  Clinical research is also an important component of my role and I am principal investigator on several trials at Sanford Health.  My overall goal is to improve the treatment for head and neck cancer patients to limit morbidity and increase efficacy and I see research and clinical trials as the main way to make progress over the next five years.

Clinical Trials

Thyroid Cancer Collaborative Registry

Understanding Head and Neck Cancer Tissue Repository

Checkmate 358 (BMS)

Merck 689

NCCORP Sponsored Trials (ECOG 0232, RTOG 9507, HN003, HN004)

Bibliography

Landeen KC, Spanos WC, Gromer L. Topical superoxide dismutase in posttreatment fibrosis in patients with head and neck cancer. Head Neck. 2018 May 13. doi: 10.1002/hed.25119. [Epub ahead of print] PubMed PMID: 29756397.

Assam JH, Spanos WC. Oral Cavity Reconstruction Outcomes Using a Porcine Urinary Bladder Matrix: A Retrospective Case Series. Wounds. 2018 May;30(5):131-137. PubMed PMID: 29847304.

Assam JH, Spanos WC. Treatment of Peritonsillar Abscess in Immunosuppressed Patients. S D Med. 2017 Jul;70(7):314-316. PubMed PMID: 28806028.

Vermeer DW, Coppock JD, Zeng E, Lee KM, Spanos WC, Onken MD, Uppaluri R, Lee JH, Vermeer PD. Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis. Oncotarget. 2016 Apr 26;7(17):24194-207. doi: 10.18632/oncotarget.8254. PubMed PMID: 27013584; PubMed Central PMCID: PMC5029694.

Coppock JD, Vermeer PD, Vermeer DW, Lee KM, Miskimins WK, Spanos WC, Lee JH. mTOR inhibition as an adjuvant therapy in a metastatic model of HPV+ HNSCC. Oncotarget. 2016 Apr 26;7(17):24228-41. doi: 10.18632/oncotarget.8286. PubMed PMID: 27015118; PubMed Central PMCID: PMC5029697.
de la Garza G, Militsakh O, Panwar A, Galloway TL, Jorgensen JB, Ledgerwood LG, Kaiser K, Kitzerow C, Shnayder Y, Neumann CA, Khariwala SS, Chad Spanos W, Pagedar NA. Obesity and perioperative complications in head and neck free tissue reconstruction. Head Neck. 2016 Apr;38 Suppl 1:E1188-91. doi: 10.1002/hed.24189. Epub 2015 Aug 13. PubMed PMID: 26268587; PubMed Central PMCID: PMC4894301.
Assam JH, Powell S, Spanos WC. Unresectable cutaneous squamous cell carcinoma of the forehead with MLH1 mutation showing dramatic response to Programmed Cell Death Protein 1 Inhibitor Therapy. Clin Skin Cancer. 2016 Jan;1(1):26-29. doi: 10.1016/j.clsc.2016.11.001. Epub 2016 Nov 23. PubMed PMID: 29333502; PubMed Central PMCID: PMC5766284.
Terrell A, Gardner P, Spanos WC, Allard B, Barth R, Bhatia V, Lee J. Clinical Outcomes of a Team Approach to Thyroidectomy. S D Med. 2015 Dec;68(12):539-41. PubMed PMID: 26793931.
Smith RB, Evasovich M, Girod DA, Jorgensen JB, Lydiatt WM, Pagedar NA, Spanos WC. Ultrasound for localization in primary hyperparathyroidism. Otolaryngol Head Neck Surg. 2013 Sep;149(3):366-71. doi: 10.1177/0194599813491063. Epub 2013 Jun 7. PubMed PMID: 23748916.
Vermeer DW, Spanos WC, Vermeer PD, Bruns AM, Lee KM, Lee JH. Radiation-induced loss of cell surface CD47 enhances immune-mediated clearance of human papillomavirus-positive cancer. Int J Cancer. 2013 Jul;133(1):120-9. doi: 10.1002/ijc.28015. Epub 2013 Feb 12. PubMed PMID: 23292955; PubMed Central PMCID: PMC3972896.
Miller RA, Spanos WC, Jassim AD. Pathology quiz case 2. Folliculitis keloidalis nuchae. JAMA Otolaryngol Head Neck Surg. 2013 Apr;139(4):425-6. doi: 10.1001/jamaoto.2013.140a. PubMed PMID: 23599087.
Wieking BG, Vermeer DW, Spanos WC, Lee KM, Vermeer P, Lee WT, Xu Y, Gabitzsch ES, Balcaitis S, Balint JP Jr, Jones FR, Lee JH. A non-oncogenic HPV 16 E6/E7 vaccine enhances treatment of HPV expressing tumors. Cancer Gene Ther. 2012 Oct;19(10):667-74. doi: 10.1038/cgt.2012.55. Epub 2012 Aug 24. PubMed PMID: 22918471; PubMed Central PMCID: PMC3571619.
Spanos WC, Nowicki P, Lee DW, Hoover A, Hostager B, Gupta A, Anderson ME, Lee JH. Immune response during therapy with cisplatin or radiation for human papillomavirus-related head and neck cancer. Arch Otolaryngol Head Neck Surg. 2009 Nov;135(11):1137-46. doi: 10.1001/archoto.2009.159. PubMed PMID: 19917928.
Spanos WC, Brookes JT, Smith MC, Burkhart HM, Bell EF, Smith RJ. Unilateral vocal fold paralysis in premature infants after ligation of patent ductus arteriosus: vascular clip versus suture ligature. Ann Otol Rhinol Laryngol. 2009 Oct;118(10):750-3. PubMed PMID: 19894404.
Spanos WC, Hoover A, Harris GF, Wu S, Strand GL, Anderson ME, Klingelhutz AJ, Hendriks W, Bossler AD, Lee JH. The PDZ binding motif of human papillomavirus type 16 E6 induces PTPN13 loss, which allows anchorage-independent growth and synergizes with ras for invasive growth. J Virol. 2008 Mar;82(5):2493-500. Epub 2007 Dec 26. PubMed PMID: 18160445; PubMed Central PMCID: PMC2258903.
Spanos WC, Geiger J, Anderson ME, Harris GF, Bossler AD, Smith RB, Klingelhutz AJ, Lee JH. Deletion of the PDZ motif of HPV16 E6 preventing immortalization and anchorage-independent growth in human tonsil epithelial cells. Head Neck. 2008 Feb;30(2):139-47. PubMed PMID: 17657785; PubMed Central PMCID: PMC2600880.
Hoover AC, Spanos WC, Harris GF, Anderson ME, Klingelhutz AJ, Lee JH. The role of human papillomavirus 16 E6 in anchorage-independent and invasive growth of mouse tonsil epithelium. Arch Otolaryngol Head Neck Surg. 2007 May;133(5):495-502. PubMed PMID: 17515506; PubMed Central PMCID: PMC2917346.
Spanos WC, El-Deiry M, Lee JH. Cidofovir incorporation into human keratinocytes with episomal HPV 16 results in nonselective cytotoxicity. Ann Otol Rhinol Laryngol. 2005 Nov;114(11):840-6. PubMed PMID: 16363057.
Tuazon PT, Spanos WC, Gump EL, Monnig CA, Traugh JA. Determinants for substrate phosphorylation by p21-activated protein kinase (gamma-PAK). Biochemistry. 1997 Dec 23;36(51):16059-64. PubMed PMID: 9405039.