American Head & Neck Society

Advancing Education, Research, and Quality of Care for the Head and Neck oncology patient.

Published on by Jennifer Anderson

Jennifer Anderson – Pittsburgh, Pennsylvania

Practice Contact Information

UPMC
203 Lothrop Street
Eye and Ear Institute
Pittsburgh
Pennsylvania
15213
United States

Phone:
Email:
Web Site:

Areas of surgical specialization in Head and Neck Surgery

Endocrine Surgery, Head and Neck Research, Head and Neck Surgeon

Biography/Statement

I completed bachelor of science degrees in mathematics and microbiology, immunology, and molecular genetics at UCLA. I studied signal transduction and targeted therapeutics as part of my PhD in molecular biology and post-doctoral work at UCLA. I then completed my medical degree at the University of California, Irvine. I am currently a fifth year resident at the University of Pittsburgh Medical Center. Next year, I will complete a fellowship in advanced head and neck surgical oncology at MD Anderson Cancer Center.

Clinical Trials

Bibliography

Published on by Wesley Stepp

Wesley Hunter Stepp – Chapel Hill, North Carolina

Practice Contact Information

University of North Carolina
170 Manning Drive
CB 7070
Chapel Hill
North Carolina
27514
United States

Phone:
Email: [email protected]
Web Site:

Areas of surgical specialization in Head and Neck Surgery

Head and Neck Research, Head and Neck Surgeon

Biography/Statement

I am a scientist and clinician working at the forefront of Otolaryngology/Head and Neck Surgery research. My work has helped to shed light on how human papillomavirus (HPV) blocks the immune system to cause cancer and how doctors can use tumor-specific therapies to improve treatment HPV-related cancers. I also developed one of the first human sinus mucosa-based infection models for SARS-CoV2, the virus that causes COVID19. I completed my PhD in Microbiology & Immunology through the National Institutes of Health and Georgetown University. I currently work with a multidisciplinary research team at the University of North Carolina at Chapel Hill in the lab, while performing clinical duties in the Department of Otolaryngology/Head & Neck Surgery. When not in the hospital or lab, I enjoy cycling, rock climbing and reading historical non-fiction.

Clinical Trials

Bibliography

Schrank TP, Landess L, Stepp WH et al. Comprehensive Viral Genotyping Reveals Prognostic Viral Phylogenetic Groups in HPV16-Associated Squamous Cell Carcinoma of the Oropharynx. Mol Cancer Res 2022.

Stepp WH*, Lopez EM, Ebert CS, Jr. et al. Site-specific detection and differential levels of immune mediators in the sinonasal mucosa. Int Forum Allergy Rhinol 2022.

*co-first authorship

 

Stepp WH*, Mahung C*, Long C et al. Early expression of IL-10, IL-12, ARG1 and NOS2 genes in peripheral blood mononuclear cells synergistically correlate with patient outcome after burn injury. J Trauma Acute Care Surg 2022.

*co-first authorship

Waters CM, Stepp WH, Conduff J et al. Anatomic Optical Coherence Tomography (aOCT) for Evaluation of the Internal Nasal Valve. Laryngoscope 2021.

Sheth, S., Farquhar, D. R., Schrank, T. P., Stepp, WH, Mazul, A., Hayward, M., Hayes, D. N. (2021). Correlation of alterations in the KEAP1/CUL3/NFE2L2 pathway with radiation failure in larynx squamous cell carcinoma. Laryngoscope Investig Otolaryngol, 6(4), 699-707. doi:10.1002/lio2.588; PMID: 34401494

Stepp WH, Farzal Z, Kimple AJ, Ebert CS Jr, Senior BA, Zanation AM, Thorp BD. HPV in the malignant transformation of sinonasal inverted papillomas: A meta-analysis. Int Forum Allergy Rhinol. 2021 May 6;. doi: 10.1002/alr.22810. PubMed PMID: 33956402; NIHMSID:NIHMS1715321.

 

Stepp WH. High-Throughput NanoString Analysis of Oncogenic Human Papillomavirus and Tumor Microenvironment Transcription in Head and Neck Squamous Cell Carcinoma. Curr Protoc. 2021 May;1(5):e146. doi: 10.1002/cpz1.146. PubMed PMID: 34033698; PubMed Central PMCID: PMC8204382.

Malfitano MJ, Santarelli GD, Gelpi M, Brown WC, Stepp WH, Hernandez S, et al. A Comparison of Sphenoid Sinus Osteoneogenesis in Aspirin-Exacerbated Respiratory Disease. Am J Rhinol Allergy. 2020:1945892420941732. Epub 2020/07/15. doi: 10.1177/1945892420941732. PubMed PMID: 32660262.

Stepp WH*, Brandon BM, Basu S, Kimbell JS, Senior BA, Shockley WW, et al. Nasal Airflow Changes With Bioabsorbable Implant, Butterfly, and Spreader Grafts. Laryngoscope. 2020. Epub 2020/05/05. doi: 10.1002/lary.28691. PubMed PMID: 32364619.

*shared first-authorship

Balakrishnan S, Bu R, Waters C, Brandon B, Kimbell J, Stepp WH, et al. Utility of endoscopic anatomical optical coherence tomography in functional rhinoplasty. J Biomed Opt. 2020;25(1):1-11. Epub 2020/01/09. doi: 10.1117/1.JBO.25.1.016001. PubMed PMID: 31912688; PubMed Central PMCID: PMCPMC7008596.

Zhang Y, Grant MS, Stepp WH, Clark LH. Clinical characteristics of CNS metastases from primary gynecologic cancers. Gynecol Oncol Rep. 2019;30:100518. Epub 2019/12/24. doi: 10.1016/j.gore.2019.100518. PubMed PMID: 31867433; PubMed Central PMCID: PMCPMC6906733.

Malfitano MJ, Norris MN, Stepp WH, Santarelli GD, Samulski TD, Senior BA, et al. Nasopharyngeal Hyalinizing Clear Cell Carcinoma: A Case Report and Review of the Literature. Allergy Rhinol (Providence). 2019;10:2152656719889030. Epub 2019/12/11. doi: 10.1177/2152656719889030. PubMed PMID: 31819807; PubMed Central PMCID: PMCPMC6883668.

Stepp WH, Farquhar D, Sheth S, Mazul A, Mamdani M, Hackman TG, et al. RNA Oncoimmune Phenotyping of HPV-Positive p16-Positive Oropharyngeal Squamous Cell Carcinomas by Nodal Status. JAMA Otolaryngol Head Neck Surg. 2018;144(11):967-75. Epub 2018/05/02. doi: 10.1001/jamaoto.2018.0602. PubMed PMID: 29710215; PubMed Central PMCID: PMCPMC6193859.

Dunn JLM, Kartchner LB, Stepp WH, Glenn LI, Malfitano MM, Jones SW, et al. Blocking CXCL1-dependent neutrophil recruitment prevents immune damage and reduces pulmonary bacterial infection after inhalation injury. Am J Physiol Lung Cell Mol Physiol. 2018;314(5):L822-L34. Epub 2018/01/26. doi: 10.1152/ajplung.00272.2017. PubMed PMID: 29368547; PubMed Central PMCID: PMCPMC6008131.

Stepp WH, Stamos JD, Khurana S, Warburton A, McBride AA. Sp100 colocalizes with HPV replication foci and restricts the productive stage of the infectious cycle. PLoS Pathog. 2017;13(10):e1006660. Epub 2017/10/03. doi: 10.1371/journal.ppat.1006660. PubMed PMID: 28968443; PubMed Central PMCID: PMCPMC5638619.

Porter SS, Stepp WH, Stamos JD, McBride AA. Host cell restriction factors that limit transcription and replication of human papillomavirus. Virus Res. 2017;231:10-20. Epub 2016/11/20. doi: 10.1016/j.virusres.2016.11.014. PubMed PMID: 27863967; PubMed Central PMCID: PMCPMC5325803.

Eitas TK, Stepp WH, Sjeklocha L, Long CV, Riley C, Callahan J, et al. Differential regulation of innate immune cytokine production through pharmacological activation of Nuclear Factor-Erythroid-2-Related Factor 2 (NRF2) in burn patient immune cells and monocytes. PLoS One. 2017;12(9):e0184164. Epub 2017/09/09. doi: 10.1371/journal.pone.0184164. PubMed PMID: 28886135; PubMed Central PMCID: PMCPMC5590883.

Van Doorslaer K, Porter S, McKinney C, Stepp WH, McBride AA. Novel recombinant papillomavirus genomes expressing selectable genes. Sci Rep. 2016;6:37782. Epub 2016/11/29. doi: 10.1038/srep37782. PubMed PMID: 27892937; PubMed Central PMCID: PMCPMC5125267.

Stepp WH, Meyers JM, McBride AA. Sp100 provides intrinsic immunity against human papillomavirus infection. mBio. 2013;4(6):e00845-13. Epub 2013/11/07. doi: 10.1128/mBio.00845-13. PubMed PMID: 24194542; PubMed Central PMCID: PMCPMC3892783.

McBride AA, Sakakibara N, Stepp WH, Jang MK. Hitchhiking on host chromatin: how papillomaviruses persist. Biochim Biophys Acta. 2012;1819(7):820-5. Epub 2012/02/07. doi: 10.1016/j.bbagrm.2012.01.011. PubMed PMID: 22306660

Published on by Joseph Lopez

Joseph Lopez – Orlando, Florida

Practice Contact Information

AdventHealth for Children
615 E PRINCETON ST
Suite 101
Orlando
Florida
32803
United States

Phone:
Email:
Web Site:

Areas of surgical specialization in Head and Neck Surgery

Endocrine Surgery, Head and Neck Research, Head and Neck Surgeon, Oral Surgeon, Reconstructive Head & Neck Surgery

Biography/Statement

Dr. Joseph Lopez earned his undergraduate degree from Stanford University and medical degree from Harvard Medical School. Dr. Lopez received his plastic surgery training at the Johns Hopkins Hospital and pursued specialty training in Pediatric Craniomaxillofacial Surgery as a Fellow at the Yale Craniofacial, Oral, and Dental Center at the Yale-New Haven Children’s Hospital.  He then completed a second fellowship in Head & Neck Surgical Oncology at the Memorial Sloan Kettering Cancer Center in New York City.

Dr. Lopez is a pediatric plastic surgeon who specializes in treating patients with conditions such as cleft lip and palate, jaw deformities (orthognathic surgery), temporomandibular joint disorders, craniosynostosis (premature closure of skull sutures resulting in abnormal skull and facial shape), obstructive sleep apnea, or syndromic anomalies like Crouzon, Apert, Pfeiffer, Treacher-Collins and Beckwith-Wiedemann, to name a few.

Dr. Lopez is also a pediatric head and neck cancer surgeon. He treats patients with benign tumors such as maxillofacial or dental cysts, vascular anomalies, and facial/neck congenital lesions as well as malignant tumors such as sarcomas. Dr. Lopez also specializes in pediatric thyroid surgery including in young children with predisposition to thyroid cancer like Multiple Endocrine Neoplasia Type 2, Familial Adematous Polyposis, or PTEN Hamartoma Tumor syndrome.

Clinical Trials

None

Bibliography

Published on by Janice Farlow

Janice Farlow – Columbus, OH

Practice Contact Information

The Ohio State University
The Ohio State University Wexner Medical Center Eye and Ear Institute
915 Olentangy River Dr., Suite 4000
Columbus
OH
43212
United States

Phone:
Email:
Web Site:

Areas of surgical specialization in Head and Neck Surgery

Endocrine Surgery, Head and Neck Research, Head and Neck Surgeon, Reconstructive Head & Neck Surgery

Biography/Statement

Dr. Janice L. Farlow, MD PhD, is currently completing a Head and Neck Surgical Oncology Fellowship at The Ohio State University Wexner Medical Center. Her research interest lies in development of personalized diagnostics, biomarkers, and treatments for head and neck malignancies. She has published and presented on topics including head and neck cancer outcomes, clinical decision support systems, organizational leadership, and medical education. She completed her residency in Otolaryngology-Head and Neck Surgery at the University of Michigan / Michigan Medicine, where she served as administrative chief resident her final year. She is a graduate of the Medical Scientist Training Program at Indiana University School of Medicine, where she completed a PhD in Medical and Molecular Genetics.

Clinical Trials

Bibliography

https://scholar.google.com/citations?user=NH11AZgAAAAJ&hl=en

https://orcid.org/0000-0003-1214-4960

https://pubmed.ncbi.nlm.nih.gov/?term=farlow+jl+%5Bauthor%5D&filter=years.2010-2022&sort=date

Published on by Joshua Kain

Joshua Kain – Houston, Texas

Practice Contact Information

Houston Methodist Hospital
6550 Fannin Street
St 1701
Houston
Texas
77030
United States

Phone: 713-441-1368
Email:
Web Site: https://www.texasheadnecksurgery.com/

Areas of surgical specialization in Head and Neck Surgery

Endocrine Surgery, Head and Neck Research, Head and Neck Surgeon, Reconstructive Head & Neck Surgery

Biography/Statement

Dr. Joshua Kain is a board-certified Otolaryngologist and fellowship-trained Head & Neck Cancer, Robotic, Skull Base and Microvascular Reconstructive Surgeon.  He is a native to the great state of Texas and proud to call this home.

He attended Texas A&M University where he was awarded his undergraduate degree with summa cum laude distinction in Biomedical Sciences.  Thereafter, he attended the McGovern Medical School (the University of Texas at Houston) and grew a deep appreciation for the vast opportunities in the Texas Medical Center.  He left the great state for internship, residency and fellowship training at the University of Alabama Birmingham hospitals and the University of California-Davis respectively prior to returning to Houston.

He specializes in benign and malignant masses of the head and neck including the mouth, face, ears, eyes, throat, salivary glands, thryoid gland, parathyroid glands and upper airway/esophagus.  This focus includes treatment of skin cancers of the scalp, face and neck.

Dr. Kain has a passion for reconstruction after cancer or traumatic injuries including specialization in microvascular tissue transplantation and grafting.  He has completed advanced training in craniomaxillofacial trauma surgery for repairs of the facial skeleton.

He is an assistant professor within the Houston Methodist Acadmic Institutute, Houston Methodist Research Institute and Weill Cornell College of Medicine.  He is a clinical adjunct faculty member for Texas A&M College of Medicine.  He is surrounded by superb, comprehensive sub-specialty trained colleagues in the Houston Methodist Department of Otolaryngology-Head & Neck Surgery under chairman Dr. Mas Takashima.

Clinical Trials

-Targeted fluorescent nerve imaging probes for intraoperative guidance

-Free flap outcomes for head and neck oncologic, congenital and traumatic reconstruction

-Intra-tumoral chemo-embolization for recurrent, advanced head and neck cancer

Bibliography

https://www.texasheadnecksurgery.com/research-innovation