Practice Contact Information

The National Cancer Center Hospital
Tsukiji5-1-1

Chuo-ku
Tokyo
1040045
Japan

Phone:
Email:
Web Site: https://www.ncc.go.jp/en/ncch/clinical_depts/Head_and_Neck_Oncology/index.html

---

Areas of surgical specialization in Head and Neck Surgery

Head and Neck Surgeon

---

Biography/Statement

EDUCATION

1991 Graduated from National Tokyo University, School of Medicine

1991-1992 Residency at Department of Otolaryngology, National Tokyo University

EMPLOYMENT

1993-1994 Fellowship at Department of Otolaryngology, Takeda General Hospital, Aiduwakamatsu-shi, Fukushima

1994-1995 Fellowship at Department of Otolaryngology, NTT east Kantou Hospital, Tokyo

1995-2008 Staff (2005- Assistant Director) at Department of Head and Neck, Cancer Institute Hospital of Japanese Foundation for Cancer Research

(2001. Apr.-Sep. University of Pittsburgh, Otolaryngology, Visit Research Fellow)

2008- Assistant Director（2013- Director）Department of Head and Neck Surgery, National Cancer Center Hospital

MEMBERSHIPS

Oto-Rhino-Laryngological Society of Japan

(Board Certified, Auris Nasus Larynx: reviewer, Japanese Board of Otolaryngology),

Japan Society for Head and Neck Cancer

(Councilor, Member of Cancer Registry Committee, Scientific Committee)

Japan Society for Head and Neck Surgery

(Board Certified, Councilor, Chief of Japanese Board of Head and Neck Surgery)

Japan Society of Clinical Oncology (Board Certified)

The Society of Swallowing and Dysphagia of Japan (Councilor)

The Japan Broncho-esophagological Society (Councilor)

American Head and Neck Society (Corresponding member)

Clinical Trials

Bibliography

1. Yoshimoto S, Kawabata K. Retropharyngeal node dissection during total pharyngolaryngectomy for hypopharyngeal cancer. ANL 32(2):163-167, 2005.
2. Yoshimoto S, Kawabata K, Mitani H, Yonekawa H, Beppu T, Fukushima H, Sasaki T. Treatment results for 84 patients with base of tongue cancer. Acta Oto-Laryngologica – Supplement, 127(559), 123 -128, 2007.
3. Yoshimoto S, Kawabata K, Mitani H. Analysis of 59 cases with free flap thrombosis after reconstructive surgery for head and neck cancer. ANL 37:205-211 2010
4. Yoshimoto S, Kawabata K, Mitani H. Factors involved in free flap thrombosis after reconstructive surgery for head and neck cancer. ANL 37:212-216 2010
5. Yoshimoto S, Hasegawa Y, Matsuzuka T, Shiotani A, Takahashi K, Kohno N, Yoshida T, Kitano H. Sentinel node biopsy for oral and laryngopharyngeal squamous cell carcinoma: a retrospective study of 177 patients in Japan. ANL 39:65-70, 2012
6. Yoshimoto S, Nakashima T, Fujii T, Matsuura K, Otsuki N, Asakage T, Fujimoto Y, Hanai N, Homma A, Monden N, Okami K, Sugasawa M, Hasegawa Y, Nibu K, Kamata S, Kishimoto S, Kohno N, Fukuda S, Hisa Y. Japanese Board Certification System for Head and Neck Surgeons. ANL 41:327–330, 2014
7. Ishibashi T, Yoshimoto S, Tsunoda R, Fukaya T, Asai M. Occult thyroid carcinoma manifested as a large mediastinal tumor. ORL J Otorhinolaryngol Relat Spec. 1997 Sep-Oct;59(5):296-9.
8. Kamata S, Kawabata K, Nigauri T, Hoki K, Mitani H, Yoshimoto S. Improved five year survival rate and quality of life with reconstructive surgery versus interstitial radiation therapy with cancer of the tongue: Analysis of long term outcome for 1190 cases between 1946 and 1995. Asian Journal of Surgery 21(4), 238-246, 1998.
9. Yokoshima K, Nigauri T, Kamata S, Kawabata K, Hoki K, Mitani H, Yoshimoto S. New classification of stage IV squamous cell carcinoma of the oropharynx. Auris Nasus Larynx. 1999 Jul;26(3):311-6.
10. Tsukahara K, Kawabata K, Mitani H, Yoshimoto S, Sugitani I, Yonekawa H, Beppu T, Fukushima H, Sasaki T. Three cases of bilateral chylothorax developing after neck dissection. Auris Nasus Larynx 2007 34:573-576
11. Ebihara Y, Watanabe K, Fujishiro Y, Nakao K, Yoshimoto S, Kawabata K, Asakage T. Carcinoid tumor of the larynx: clinical analysis of 33 cases in Japan. Acta Otolaryngol Suppl. 2007 Dec;(559):145-50.
12. Orita Y, Kawabata K, Mitani H, Fukushima H, Tanaka S, Yoshimoto S, and Yamamoto N. Can narrow－band imaging be used to determine the surgical margin of superficial hypopharyngeal cancer? Acta Med. Okayama 62(3): 205-208, 2008.
13. Tsukahara K, Yoshimoto S, Sasaki T, et al: Report of a case of submandibular hypoglossal neurinoma. Indian Journal of Otolaryngology and Head & Neck Surgery 62 (Suppl. 2): S212-S214, 2010
14. Ohtomo R, Mori T, Shibata S, Tsuta K, Maeshima AM, Akazawa C, Watabe Y, Honda K, Yamada T, Yoshimoto S, Asai M, Okano H, Kanai Y, Tsuda H: SOX10 is a novel marker of acinus and intercalated duct differentiation in salivary gland tumors: a clue to the histogenesis for tumor diagnosis. Mod Pathol. 2013 Aug;26(8):1041-50.
15. Yamazaki H, Mori T, Yazawa M, Maeshima AM, Matsumoto F, Yoshimoto S, Ota Y, Kaneko A, Tsuda H, Kanai Y: Stem cell self-renewal factors Bmi1 and HMGA2 in head and neck squamous cell carcinoma: clues for diagnosis. Lab Invest. 2013 Dec;93(12):1331-8.
16. Fukunaga Y, Sakuraba M, Miyamoto S, Kayano S, Kurosawa K, Fujiki M, Sakisaka M, Yoshimoto S. One-stage reconstruction of a tracheal defect with a free radial forearm flap and free costal cartilage grafts. J Plast Reconstr Aesthet Surg. 67:857-9, 2014
17. Watabe Y, Mori T, Yoshimoto S, Nomura T, Shibahara T, Yamada T, Honda K. Copy number increase of ACTN4 is a prognostic indicator in salivary gland carcinoma. Cancer Med. 3:613-22, 2014
18. Murakami N, Mori T, Yoshimoto S, Ito Y, Kobayashi K, Ken H, Kitaguchi M, Sekii S, Takahashi K, Yoshio K, Inaba K, Morota M, Sumi M, Itami J. Expression of EpCAM and prognosis in early-stage glottic cancer treated by radiotherapy. Laryngoscope. 124:E431-6, 2014
19. Murakami N, Yoshimoto S, Matsumoto F, Ueno T, Ito Y, Watanabe S, Kobayashi K, Harada K, Kitaguchi M, Sekii S, Takahashi K, Yoshio K, Inaba K, Morota M, Sumi M, Saito Y, Itami J. Severe gastrointestinal bleeding in patients with locally advanced head and neck squamous cell carcinoma treated by concurrent radiotherapy and Cetuximab. J Cancer Res Clin Oncol. 141:177-84, 2015
20. Kinjo Y, Nonaka S, Oda I, Abe S, Suzuki H, Yoshinaga S, Maki D, Yoshimoto S, Taniguchi H, Saito Y. The short-term and long-term outcomes of the endoscopic resection for the superficial pharyngeal squamous cell carcinoma. Endosc Int Open. 2015 Aug;3(4):E266-73.
21. Wakisaka N, Hasegawa Y, Yoshimoto S, Miura K, Shiotani A, Yokoyama J, Sugasawa M, Moriyama-Kita M, Endo K, Yoshizaki T. Primary Tumor-Secreted Lymphangiogenic Factors Induce Pre-Metastatic Lymphvascular Niche Formation at Sentinel Lymph Nodes in Oral Squamous Cell Carcinoma. PLoS One. 2015 Dec 2;10(12)
22. Yoshida A, Goto K, Kodaira M, Kobayashi, E, Kawamoto H, Mori T, Yoshimoto S, Endo O, Kodama N, Kushima R, Hiraoka N, Motoi T, MD, Kawai A. CIC-rearranged Sarcomas: A Study of 20 Cases and Comparisons with Ewing Sarcomas　　Am J Surg Pathol. 2016 Mar;40(3):313-23
23. Murakami N, Matsumoto F, Yoshimoto S, Ito Y, Mori T, Ueno T, Tuchida K, Kashihara T, Kobayashi K, Harada K, Kitaguchi M, Sekii S, Umezawa R, Takahashi K, Inaba K, Igaki H, Itami J. Patterns of recurrence after selective postoperative radiation therapy for patients with head and neck squamous cell carcinoma. BMC Cancer. 2016 Mar 7;16(1):192.
24. Ohtomo-Oda R, Komatsu S, Mori T, Sekine S, Hirajima S, Yoshimoto S, Kanai Y, Otsuji E, Ikeda E, Tsuda H. SMYD2 overexpression is associated with tumor cell proliferation and a worse outcome in human papillomavirus-unrelated nonmultiple head and neck carcinomas. Hum Pathol. 2016 Mar;49:145-55.
25. Hirokawa M, Sugitani I, Kakudo K, Sakamoto A, Higashiyama T, Sugino K, Toda K, Ogasawara S, Yoshimoto S, Hasegawa Y, Imai T, Onoda N, Orita Y, Kammori M. Histopathological analysis of anaplastic thyroid carcinoma cases with long-term survival: A report from the Anaplastic Thyroid Carcinoma Research Consortium of Japan Endocr J. 2016 Feb 3. [Epub ahead of print]
26. Kobayashi K, Kurihara H, Watanabe Y, Murakami N, Inaba K, Nakamura S, Wakita A, Okamoto H, Umezawa R, Takahashi K, Igaki H, Ito Y, Yoshimoto S, Shigematsu N, Itami J. In Vivo Spatial Correlation Between 18F-BPA and 18F-FDG Uptakes in Head and Neck Cancer. Appl Radiat Isot. 2016 Sep;115:138-46.
27. Miura K, Hirakawa H, Uemura H, Yoshimoto S, Shiotani A, Sugasawa M, Homma A, Yokoyama J, Tsukahara K, Yoshizaki T, Yatabe Y, Matsuo K, Ohkura Y, Kosuda S, Hasegawa Y. entinel node biopsy for oral cancer: A prospective multicenter Phase II trial. ANL 2016 Aug 2 [Epub ahead of print]
28. Kobayashi K, Matsumoto F, Kodaira M, Mori T, Murakami N, Yoshida A, Maki D, Teshima M, Fukasawa M, Itami J, Asai M, Yoshimoto S. Significance of delayed primary excision in localized nonmetastatic adult head and neck rhabdomyosarcoma. Cancer Med. 2016 Aug 26. [Epub ahead of print]
29. Maki D, Mori T, Teshima M, Kobayashi K, Matsumoto F, Sakai A, Okami K, Yoshimoto S. Chondrosarcoma of the hyoid bone – Report of a case and a literature review of the suitable treatment strategy. ANL 2016 Oct 18. [Epub ahead of print]
30. Kobayashi K, Mori T, Matsumoto F, Murakami N, Teshima M, Fukasawa M, Matsumoto Y, Matsumura S, Itami J, Asai M, Yoshimoto S. Impact of microscopic orbital periosteum invasion in orbital preservation surgery. JJCO 2017, 1–7
31. Kakuya T, Mori T, Yoshimoto S, Watabe Y, Miura N, Shoji H, Onidani K, Shibahara T, Honda K. Prognostic significance of gene amplification of ACTN4 in stage I and II oral tongue cancer. Int J Oral Maxillofac Surg. 2017 Aug;46(8):968-976
32. Rikitake R, Ando M, Saito Y, Yoshimoto S, Yamasoba T, Higashi T. Current status of superficial pharyngeal squamous cell carcinoma in Japan. Int J Clin Oncol. 2017 Oct;22(5):826-833
33. Matsumoto F, Mori T, Matsumura S, Matsumoto Y, Fukasawa M, Teshima M, Kobayashi K, Yoshimoto S. Prognostic significance of surgical extranodal extension in head and neck squamous cell carcinoma patients. Jpn J Clin Oncol. 2017 Apr 18:1-6.
34. Kobayashi K, Matsumoto F, Miyakita Y, Mori T, Shimoi T, Murakami N, Yoshida A, Arakawa A, Omura G, Fukasawa M, Matsumoto Y, Matsumura S, Itami J, Narita Y, Yoshimoto S. Impact of surgical margin in skull base surgery for head and neck sarcomas. J Neurol Surg B Skull Base 2018