AHNS Oral Presentations

AHNS01
HPV+ OPSCC recurrence risk after TORS is associated with a smaller fraction of tumor cells containing detectable E6/E7 RNA

Jean-Nicolas Gallant, MD, PhD¹; Malay K Sannigrahi, PhD¹; Lovely Raghav, PhD¹; David Shimunov, MD²; Robert M Brody, MD¹; Phyllis A Gimotty, PhD¹; Jalal Jalaly, MD¹; Devraj Basu, MD, PhD¹; ¹The University of Pennsylvania; ²SUNY Stonybrook

AHNS02
The Performance of Tumor Tissue Modified Viral-Human Papillomavirus, An Institutional Update

Peter Cooke¹; Susmita Chennareddy²; Daniel Kraft¹; Joseph Correa¹; Sida Chen¹; Catharine Kappauf¹; Kunal Sindhu³; Rocco Ferrandino⁴; Krzysztof Misiukiewicz⁵; Richard Bakst³; Marshall Posner⁵; Mohemmed Khan¹; Marita Teng¹; Eric Genden¹; Raymond Chai¹; Scott Roof¹; ¹Mount Sinai Department of Otolaryngology; ²Icahn School of Medicine at Mount Sinai; ³Mount Sinai Department of Radiation Oncology; ⁴UW Medicine Department of Otolayngology; ⁵Mount Sinai Department of Hematology-Oncology

AHNS03
Neoadjuvant chemotherapy and transoral robotic surgery as definitive treatment in p16+ve oropharyngeal cancer: Outcomes of NECTORS trial

Nader Sadeghi, MD¹; M Mascarella, MD¹; K Richardson, MD¹; A Zeitouni¹; Jessica Hier, MD²; N. Golabi, MSc³; L Anthonanzas⁴; D Caglar¹; K Sultanem, MD²; C Tsien, MD¹; G Shenouda, MD¹; K. Esfahani, MD²; A Mlynarek, MD²; M Hier, MD²; N Bouganim, MD¹; ¹McGill University Health Centre; ²McGill University; ³Research Institute of McGill University Health Centre; ⁴Jewish General Hospital

AHNS04
Circulating tumor HPV-DNA and Chemotherapy Response in HPV-Associated Oropharyngeal Cancer

Augustin G Vannier¹; Evgeny Izumchenko, PhD²; Aditya Juloori, MD³; Rohan Katipally, MD³; Elizabeth Blair, MD⁴; Mark Lingen, DDS, PhD⁵; Nicole Cipriani, MD⁵; Rifat Hasina, DDS, PhD⁴; Daniel Haraf, MD³; Everett E Vokes, MD²; Nishant Agrawal, MD⁴; Alexander T Pearson, MD, PhD²; Ari J Rosenberg²; ¹Pritzker School of Medicine, University of Chicago, Chicago, IL; ²Section of Hematology / Oncology, University of Chicago, Chicago, IL; ³Department of Radiation Oncology, University of Chicago, Chicago, IL; ⁴Section of Otolaryngology - Head and Neck Surgery, University of Chicago, Chicago, IL; ⁵Department of Pathology, University of Chicago, Chicago, IL

AHNS05
Postoperative Circulating Tumor HPV DNA Kinetics in Surgically Managed Patients with HPV(+)OPSCC

Cecelia M Hidalgo, BA¹; Aaron W Bogan, MA¹; Linda X Yin, MD¹; Danielle E Hunter¹; Kathleen R Bartemes, PhD¹; Kendall K Tasche, MD¹; David M Routman, MD²; Kathryn M Van Abel, MD¹; ¹Department of Otorhinolaryngology-Head and Neck Surgery, Mayo Clinic; ²Department of Radiation Oncology, Mayo Clinic

AHNS06
Post-Diagnosis Smoking Cessation and Its Effect on Survival Outcomes in Head and Neck Cancer Patients: Findings from a Prospective Cohort Study

Elham Mohebbi¹; Garret Guthrie¹; Siddhi Patil¹; Ruzong Fan¹; Ming Tan¹; Gregory Wolf²; Laura Rozek¹; ¹Georgetown University Medical Center; ²University of Michigan Medical Center

AHNS07
Beyond aspiration: revisiting residue rates and MBS swallow profiles from the ECOG-ACRIN E3311 trial

Beatrice Manduchi, PhD¹; Yael Flamand²; Robert L Ferris³; Harry Quon⁴; Gregory S Weinstein⁵; Ranee Mehra⁶; Joaquín J García⁷; Christine Peterson⁸; Carly E Barbon⁸; Jan S Lewin⁸; Umamaheswar Duvvuri³; Enver Ozer⁹; Neil B Gross⁸; R. Bryan Bell¹⁰; Nabil F Saba¹¹; Wayne M Koch⁴; Francisco Civantos¹²; Tom Thomas¹³; Russell Smith¹⁴; Floyd Holsinger¹⁵; Saral Mehra¹⁶; Thomas Gal¹⁷; Barbara Burtness¹⁶; Katherine A Hutcheson⁸; ¹The University of Texas Health Science Center at Houston; ²Dana Farber Cancer Institute - ECOG-ACRIN Biostatistics Center; ³UPMC Hillman Cancer Center; ⁴Johns Hopkins University; ⁵University of Pennsylvania; ⁶University of Maryland/Greenebaum Cancer Center; ⁷Mayo Clinic; ⁸MD Anderson Cancer Center; ⁹Ohio State University; ¹⁰Providence Cancer Institute; ¹¹Winship Cancer Institute, Emory University; ¹²University of Miami Miller School of Medicine; ¹³Dana-Farber/Harvard Cancer Center; ¹⁴Nebraska Methodist Hospital; ¹⁵Stanford Cancer Institute Palo Alto; ¹⁶Yale University; ¹⁷University of Kentucky/Markey Cancer Center

AHNS08
Efficacy of a Brief Cognitive Behavioral Therapy for Head and Neck Cancer Survivors Across Domains of Body Image Distress: Secondary Outcomes from the BRIGHT Pilot Randomized Clinical Trial

Haley Hullfish, MD¹; Emily Kistner-Griffin, PhD¹; Stacey Maurer, PhD¹; Wendy Balliet, PhD¹; Jessica Vanderlan, PhD²; Olga Slavin-Spenney, PhD³; Lynne Padgett, PhD⁴; Angie Rush⁵; Brad Johnson⁵; Taylor McLeod, MPH¹; Ella J Starr, MPH¹; Kenneth J Ruggiero, PhD¹; Katherine R Sterba, PhD, MPH¹; Evan Graboyes, MD, MPH¹; ¹Medical University of South Carolina; ²Washington University School of Medicine; ³Henry Ford Cancer Institute; ⁴National Institute on Minority Health and Health Disparities; ⁵Head and Neck Cancer Alliance

AHNS09
Variations in clinical presentation and physician decision-making between frail and not-frail head and neck cancer patients

Eoin F Cleere; Gerard Sexton; Justin M Hintze; James Griffin; Conrad V Timon; John Kinsella; Paul Lennon; Conall W Fitzgerald; St James' Hospital, Dublin, Ireland

AHNS10
Clinical and sociodemographic determinants of sustained head and neck cancer survivorship clinic attendance

Maryanna S Owoc, MD, PhD¹; Katie M Carlson, MPH¹; Marci Lee Nilsen, PhD, RN, CHPN¹; Kevin Contrera, MD¹; Yvonne M Mowery, MD, PhD²; Jonas Johnson, MD¹; Angela L Mazul, PhD, MPH¹; ¹University of Pittsburgh Medical Center Department of Otolaryngology-Head and Neck Surgery; ²University of Pittsburgh Medical Center Department of Radiation Oncology

AHNS11
Five-year OS and DFS in HPV-associated HNSCC following neoadjuvant immunotherapy + GTV-only SBRT from the Providence NIRT-1 study

Robert H Hermann¹; Rom Leidner¹; Marka Crittendon¹; Kristina Young¹; Ashish A Patel²; Allen C Cheng²; George Morris³; Lessli Rushforth³; Hong Xiao³; Carlo Bifulco¹; Walter J Urba¹; Michael Gough¹; Alexa K Dowdell¹; Ryan Meng¹; Brian D Piening¹; R. Bryan Bell¹; ¹Earle A. Chiles Research Institute, Portland, OR; ²Head and Neck Surgical Associates; ³Providence Cancer Institute

AHNS12
Investigating the Role of Regulatory T Cells in Pathologic Response to Different Neoadjuvant Immune Checkpoint Inhibitor (ICI) Combinations in HNSCC

Matthias Brand, MD¹; Aditi Kulkarni¹; Housaiyin Li²; Upadhyay Pragati¹; Simon I Chiosea, MD³; Patricia M Santos, PhD¹; Brian Isett, PhD¹; Marion Joy, PhD¹; Gabriel Sica, MD, PhD³; Umamaheswar Duvvuri, MD, PhD⁴; Seungwon Kim, MD¹; Mark Kubik, MD¹; Fei Tu, PhD¹; Tullia C Bruno, PhD¹; Dario A A Vignali, PhD⁵; Anthony R Cillo, PhD¹; Riyue Bao, PhD¹; Dan P Zandberg, MD¹; Jing Hong Wang, MD, PhD¹; Lazar Vujanovic, PhD¹; Robert L Ferris, MD, PhD⁶; ¹UPMC Hillman Cancer Center; ²Molecular Genetics and Development Biology Graduate Program, University of Pittsburgh; ³Department of Pathology, University of Pittsburgh; ⁴Department of Otolaryngology, NYU Grossman School of Medicine; ⁵Department of Immunology, University of Pittsburgh; ⁶UNC Lineberger Comprehensive Cancer Center

AHNS13
A Phase 2, Open-Label Study of Intratumoral Vidutolimod in Combination With Intravenous Pembrolizumab in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Deborah J Wong¹; Lori Wirth²; Douglas Laux³; Ammar Sukari⁴; Mirabelle Sajisevi⁵; Dan Paul Zandberg⁶; Assuntina Sacco⁷; Jacob Thomas⁸; Aru Panwar⁹; Jun Zhang¹⁰; Robert Siegel¹¹; Mia Bao¹²; Jocelyn Booth¹²; Christy French¹²; Israel Lowy¹²; Matthew Fury¹²; Mihaela Cristea¹²; ¹University of California Los Angeles Medical Center; ²Massachusetts General Hospital; ³University of Iowa Hospitals & Clinics; ⁴Karmanos Cancer Institute; ⁵University of Vermont Medical Center; ⁶University of Pittsburgh Medical Center - Hillman Cancer Center; ⁷University of California, San Diego; ⁸University of Southern California; ⁹Nebraska Methodist Hospital; ¹⁰Houston Methodist Hospital; ¹¹St. Francis Cancer Center; ¹²Regeneron Pharmaceuticals, Inc.

AHNS14
Chemo-Immunotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma: The MD Anderson Experience

Shorook Naara, MD, PhD; Stephanie Zhang; Sophie Li; Ryan Goepfert, MD; Neal Akhave, MD; Luana Guimaraes De Sousa, MD; Neil Gross, MD; Ehab Hanna; Jeffrey Myers, MD, PhD; Moran Amit, MD, PhD; University of Texas, MD Anderson Cancer Center

AHNS15
Validation of a Peripheral Blood Prognostic Signature for Overall Survival in Head and Neck Squamous Cell Carcinoma Treated With Immune Checkpoint Inhibitors and Comparison to the Systemic Inflammatory Response Index (SIRI)

Cassie Pan¹; Sina Dadafarin¹; Kevin Ng²; Jenna Voutsinas²; Armita Norouzi¹; Jeffrey J Houlton³; Brittany Barber¹; Zain H Rizvi¹; Emily Marchiano¹; Rocco M Ferrandino¹; Neal Futran¹; George E Laramore¹; Jay J Liao¹; Upendra Parvathaneni¹; Neil Panjwani¹; Cristina P Rodriguez¹; Qian "Vicky" Wu²; ¹University of Washington; ²Fred Hutchinson Cancer Research Center; ³Head and Neck Specialists

AHNS16
scRNA-seq and genomics analyses reveal key mechanisms of inverted papilloma-associated sinonasal squamous cell carcinoma malignant transformation

Tolani Olonisakin, MD, PhD¹; Kenny Vu, MS²; Xinping Yang²; Aaron Udager, MD³; Clint Allen, MD²; Nyall London, MD, PhD²; ¹Johns Hopkins Medicine; ²National Cancer Institute/National Institutes of Health; ³University of Michigan

AHNS17
Establishing a Patient-Derived Xenograft Library for Head and Neck Cancer: Unveiling Mechanisms of Adaptive Chemotherapy Resistance

Chikako Yagi, MD¹; Hisano Yanagi²; Takashi Watanabe³; Tomoki Kuki¹; Yasuyoshi Mizutani⁴; Seiji Yamada³; Tetsuya Takimoto³; Motoshi Suzuki⁴; Kenji Kawada²; Hideyuki Saya³; Hisayuki Kato¹; Ichiro Tateya¹; ¹Department of Otolaryngology-Head and Neck Surgery, Fujita Health Univercity; ²Department of Clinical Oncology, Fujita Health University; ³Oncology Innovation Center, Fujita Health University; ⁴Department of Molecular Oncology, Fujita Health University

AHNS18
The Epigenetic link between Psychosocial Stress and Survival of Oral Squamous Cell Carcinoma

Traeden D Wilson, MD¹; Phuong Dong, PhD²; Bac-An Luong²; Gary Yu, DrPH, MPH³; Michele Arambula²; Bradley Aouizerat, PhD⁴; Paul Walker, MD¹; Khahn Nguyen, MD¹; Nicholas Callahan, MPH, DMD, MD⁵; Carissa Thomas, MD, PhD, FACS⁶; Chi Viet, DDS, MD, PhD, FACS²; ¹Loma Linda University Department of Otolaryngology; ²Loma Linda University School of Dentistry; ³Columbia University; ⁴New York University College of Dentistry; ⁵University of Illinois Chicago College of Dentistry; ⁶University of Colorado Department of Otolaryngology

AHNS19
Intratumoral Chemokine Priming Enhances Immune Surveillance and Potentiates Checkpoint Inhibition in Head and Neck Cancer

Robert Saddawi-Konefka; Cheyanne Shinn; Cynthia Tang; Ning Kuo; Shiruyeh Schokrpur; Tracy Handel; J. Silvio Gutkind; University of California, San Diego

AHNS20
Epigenomic features and vulnerabilities of head and neck squamous cell carcinoma metastasis

Wesley L Cai, MD, PhD¹; Baris Sergi, BS²; Chareeni E Kurukulasuriya³; Ceyda Acilan, PhD²; Umamaheswar Duvvuri, MD, PhD³; ¹University of Pittsburgh Medical Center; ²Koc University; ³New York University Langone Health

AHNS21
Virtual Surgical Planning as an Educational and Reconstructive Tool in Head and Neck Outreach: A Collaborative Mission in Uganda

Isaac Mukiibi¹; Alexander Karabachev²; Priscilla Pichardo²; Katrina Harrill²; Chad Zender²; Jeff Otiti¹; ¹Makerere University and Uganda Cancer Institute Surgical Oncology Division; ²University of Cincinnati Department of Otolaryngology Head and Neck Surgery

AHNS22
Virtual Reality Simulation for Fibula Free Flap Planning among an Otolaryngology-Head and Neck Surgery Resident Cohort

Hannah L Kenny, MD; Kathryn Nunes, BS; Kelly M Bridgham, MD; Eric V Mastrolonardo, MD; Joseph M Curry, MD; Richard A Goldman, MD; Thomas Jefferson University Hospital

AHNS23
Benchmarking the Competency, Credibility and Consistency of ChatGPT-4o

Yash V Shroff, BA¹; Rohith R Kariveda, BA¹; Jessica R Levi, MD²; ¹Boston University Chobanian & Avedisian School of Medicine; ²Department of Otolaryngology - Head and Neck Surgery, Boston Medical Center

AHNS24
Evaluating the Impact of Multimedia on Patient Comprehension and Decision-Making in Thyroid Surgery: A Randomized Controlled Trial of the Thyroid Informed Surgical Consent Augmenting Video (TISCAV)

Hani Samarah, BS; Kathryn Nunes, BS; Kalena Liu, BS; Annie Moroco, MD; Joseph Curry, MD; Elizabeth Cottrill, MD; Thomas Jefferson University

AHNS25
Development and Pilot Testing of a High-Fidelity Transoral Robotic Surgery Simulator

Brett Campbell; Lauren Schlegel; Scharukh Jalisi; Ernest Gomez; Beth Israel Deaconess Medical Center

AHNS26
Neoadjuvant BRAF/MEK inhibitor therapy and immunotherapy for BRAFV600E-mutated anaplastic thyroid cancers

Isabelle Fournier, MD, FRCSC; Anastasios Maniakas, MD, PhD, FRCSC; Jennifer Rui Wang, MD, PhD, ScM, FRCSC; Victoria E. Banuchi, MD, MPH; Stephen Y. Lai, MD, PhD, FACS; Maria Gule-Monroe, MD; Shekhar D. Khanpara, MD; Matthew S. Ning, MD, MPH; Michelle D. Williams, MD; Xu Li, PhD; Ramona Dadu, MD; Naifa L. Busaidy, MD, FACP, FACE; Priyanka Iyer, MBBS; Sarah Hamidi, MD, FRCPC; Maria E. Cabanillas, MD; Mark E. Zafereo, MD, FACS; MD Anderson Cancer Center

AHNS27
Utilization of Immunotherapy in Anaplastic Thyroid Cancer: Impact on Survival and Disparities in Access

Josef Madrigal, MD; Sara Sakowitz, MS, MPH; Matthew E Lin, MD; Lauran K Evans, MD; Peyman Benharash, MD; Maie A St. John, MD, PhD; University of California, Los Angeles

AHNS28
Association of Socioeconomic, Neighborhood, and Institutional Factors with Presentation in Differentiated Thyroid Cancer: A Population-Based Study of California from 1988 to 2020

Nazineen Kandahari, MD, MS¹; Mindy C DeRouen, PhD, MPH²; Stephen Li MPH²; Trevor G Hackman, MD, FACS¹; Gregory W Randolph, MD, FACS, FACE³; Marika D Russell, MD, FACS³; ¹Department of Otolaryngology, University of North Carolina-Chapel Hill; ²Department of Epidemiology and Biostatistics, University of California, San Francisco; ³Department of Otolaryngology, Harvard Medical School and Massachusetts Eye and Ear Infirmary

AHNS29
Hypoparathyroidism After Total Thyroidectomy: A Quality of Life Randomized Controlled Trial Comparing Two Treatment Strategies

Catherine Beaumont, MD, MSc¹; Francis Gilbert, MD, FRCSC²; Rémy-Thomas Couture, MD³; Nathalie Audet, MD, FRCSC¹; Danielle Beaudoin, MD, FRCSC¹; Jean-Philippe Vézina, MD, FRCSC¹; ¹CHU de Québec - Université Laval, ENT-H&N Surgery Department; ²CISSS de Chaudière-Appalaches and Université Laval, ENT-H&N Surgery Department; ³Centre hospitalier universitaire de Sherbrooke, ENT-H&N Surgery Department

AHNS30
Is thyroid lobectomy plus neck dissection an effective treatment option in select patients with N1b papillary thyroid carcinoma?

Daniel W Scholfield; Alana Eagan; Fergal Kavanagh; Giovanna Caxeiro; Helena Levyn; R M Tuttle; Richard J Wong; Jatin P Shah; Ashok R Shaha; Snehal G Patel; Ian Ganly; Memorial Sloan Kettering Cancer Center

AHNS31
Taxane, platinum and cetuximab-based neoadjuvant chemotherapy for patients with locally advanced oral cavity squamous cell carcinoma results in improved survival compared to propensity matched cohort

Kenric Tam, MD; Giovanna Caxeiro, MD; Winston Wong; Alana Eagan, MPH; Marc A Cohen, MD, MPH; Richard J Wong, MD, FACS; Alan L Ho, MD, PhD; Lara A Dunn; Jennifer R Cracchiolo, MD; Snehal G Patel, MD, FRCS; Ian Ganly, MD, PhD; Memorial Sloan-Kettering Cancer Center

AHNS32
Machine Learning to Differentiate Mucosal Lesions from Laryngeal Immobility Using Voice Recordings

Robin Baudouin; Clemence Forges; Stanislas Nicolleau; Stephane Hans, MD, PhD; Hopital Foch

AHNS34
Determined at the Margins: Examining the Risk of Dysplastic Margins after Primary Surgery for Oral Cavity SCC

Jae Gardella¹; Robert Balsiger, MD²; Kevin Lee, MD, DDS³; Vishal Gupta, MD⁴; Ryan McSpadden, MD⁴; Kimberly Wooten, MD⁴; Wesley L Hicks Jr., MD⁴; Ayham Al Afif, MD⁵; ¹Weill Cornell Medicine; ²Jacobs School of Medicine; ³University of Washington Medicine; ⁴Roswell Park Comprehensive Cancer Center; ⁵Dalhousie Medicine

AHNS35
Trends in Initial Management of T4 Laryngeal Squamous Cell Carcinoma

Annie J Orr, MD¹; Michael C Topf, MD, MSCI²; Robert P Zitsch III, MD¹; Patrick T Tassone, MD, MSAM, FACS¹; ¹University of Missouri; ²Vanderbilt University Medical Center

AHNS36
Circulating tumor DNA (ctDNA) in the Diagnosis and Surveillance of HPV-negative Oral Cavity Carcinoma

Hannah Q Baratz, BS¹; Linda X Yin, MD¹; Kendall K Tasche, MD¹; Scott C Lester, MD²; Eric J Moore, MD¹; David M Routman, MD²; Katharine R Price, MD³; Daniel J Ma, MD²; Kathryn M Van Abel, MD¹; Michelle A Neben Wittich, MD²; Yan Li, PhD¹; Daniel L Price, MD¹; ¹Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic; ²Department of Radiation Oncology, Mayo Clinic; ³Department of Oncology, Mayo Clinic

AHNS37
Distinct bacterial signatures and metagenomic alterations associated with lymph node metastasis in laryngeal cancer

David R Hoying, BS¹; Xi Qiao, PhD¹; Akeesha Shah, MD²; Radhika Duggal, BS¹; Jin Dai, PhD²; Nandini Rajaram Siva, MD¹; August Culbert, BS¹; Travis Kerr²; Kristianna Fredenburg, MD, PhD³; Apollo Stacy, PhD²; Adam Burgener, PhD¹; Jamie Ku, MD²; Joseph Scharpf, MD²; Brandon Prendes, MD²; Eric Lamarre, MD²; Danielle Botallico, MD²; Jacob Miller, MD²; Shlomo Koyfman, MD²; Neil Woody, MD²; Shauna Campbell, MD²; Jessica Geiger²; Tamara Sussman, MD²; Tim Chan, MD, PhD²; Liangliang Zhang, PhD¹; Daniel McGrail, PhD²; Natalie Silver, MD²; ¹Case Western Reserve University; ²Cleveland Clinic; ³University of Florida