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Published on January 21, 2016 by AHNS Webmaster

Cancer of the Oropharynx: Risk Factors, Diagnosis, Treatment, and Outcomes

Frequently Asked Questions (FAQ)

  1. Can one get oropharyngeal cancer through kissing?  This is not fully known.  It is thought that deep kissing is a risk factor. Studies have shown that increased number of lifetime sexual partners is a risk factor for developing HPV-related throat cancer.
  1. What are the ways one can avoid getting oropharyngeal cancer?  Currently, Guardasil, the tetravalent HPV vaccine (covers high risk HPV subtypes 6, 11,16 18), is the best recommendation for avoidance of HPV-related throat cancer.  However, it will work only for those patients who have not been exposed to the virus. Thus, the recommendation from the Centers for Disease Control (CDC) is to vaccinate boys and girls before they become sexually active. 
  1. If my partner has oropharyngeal cancer what is my risk of getting oropharyngeal cancer?  This is currently unknown.  However, there are no studies showing partners of patients with HPV-related throat cancers are higher risk in developing the disease than the general population.  For those, patients with partners who have HPV-related throat cancers, currently there are no recommendations for vaccination, nor avoidance.  It has to be kept in mind only a small portion of patients who carry the high risk HPV virus in their throat, will develop the disease.
  1. Is there a test available to tell me if I have the high risk HPV virus in my throat?  No, currently there are no commercially available tests to check for the virus in the throat.

 

References

Centers for Disease Control and Prevention (CDC). Human papilloma virus- associated cancers- United States, 2004-2008. MMWR Morb Mortal Wkly Rep 2012; 61:258-61

Siegel R, Ward E, Brawley O, et al. Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 2011; 61:212-36

Jemal A, Simard EP, Dorell C,  et al. Annual Report to the Nation on the Status of Cancer, 1975-2009, featuring the burden and trends in human papillomavirus (HPV)-associated cancers and HPV vaccination coverage levels. J Natl Cancer Inst. 2013 Feb 6;105(3):175-201

Sturgis EM, Cincirpini PM. Trends in head and neck cancer incidence in relation to smoking prevalence; an emerging epidemic of human papillomavirus-associated cancers? Cancer 2007; 110:1429-35

Sturgis EM, Wei Q, Spitz MR. Descriptive epidemiology and risk factors for head and neck cancer. Semin Oncol 2004; 31:726-33.

Mashberg A, Boffetta P, Winkelman R et al. Tobacco smoking, alcohol drinking, and cancer of the oral cavity and oropharynx among US veterans. Cancer 1993; 72: 1369–1375.

Bagnardi V, Rota M, Botteri E, et al. Light alcohol drinking and cancer: a meta-analysis. Annals of Oncology 2013; 24: 301–308

Mariolis P, Rock VJ, Asman K, et al. Tobacco use among adults- United States, 2005. MMWR Morb Mortal Wkly Rep 2006; 55:1145–1148

Gillison ML, D’Souza G, Westra W, et al. Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. J Natl Cancer Inst. 2008;100(6):407-20

Gillison ML, Broutian T, Pickard RK, et al. Prevalence of oral HPV infection in the United States, 2009-2010. JAMA 2012;307:693-703

Sanders AE, Slade GD, Patton LL. National prevalence of oral HPV infection and related risk factors in the U.S. adult population. Oral Dis 2012; 18:430-41

Heck JE, Berthiller J, Vaccarella S, et al. Sexual behaviours and the risk of head and neck cancers: a pooled analysis in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Int J Epidemiol. 2010; 39(1):166-81

Skinner HD, Holsinger FC, Beadle BM. Oropharynx cancer. Curr Probl Cancer 2012; 36:334-415

Divaris K, Olshan AF, Smith J, et al. Oral health and risk for head and neck squamous cell carcinoma: the Carolina Head and Neck Cancer Study. Cancer Causes Control 2010; 21:567-75

Lucenteforte E, Garavello W, Bosetti C, et al. Dietary factors and oral and pharyngeal cancer risk. Oral Oncol 2009;45:461-7

Kelly, K., S. Johnson-Obaseki, J. Lumingu and M. Corsten (2014). Oncologic, functional and surgical outcomes of primary Transoral Robotic Surgery for early squamous cell cancer of the oropharynx: A systematic review. Oral Oncol. 2014 Aug;50(8):696-703

Lee, S. Y., Y. M. Park, H. K. Byeon, E. C. Choi and S. H. Kim (2013). Comparison of oncologic and functional outcomes after transoral robotic lateral oropharyngectomy versus conventional surgery for T1 to T3 tonsillar cancer. Head Neck, 2014 Aug;36(8):1138-45.

Moore, E. J., S. M. Olsen, R. R. Laborde, J. J. Garcia, F. J. Walsh, D. L. Price, J. R. Janus, J. L. Kasperbauer and K. D. Olsen (2012). Long-term functional and oncologic results of transoral robotic surgery for oropharyngeal squamous cell carcinoma. Mayo Clin Proc 87(3): 219-225.

More, Y. I., T. T. Tsue, D. A. Girod, J. Harbison, K. J. Sykes, C. Williams and Y. Shnayder (2013). Functional swallowing outcomes following transoral robotic surgery vs primary chemoradiotherapy in patients with advanced-stage oropharynx and supraglottis cancers. JAMA Otolaryngol Head Neck Surg 139(1): 43-48.

Park, Y. M., W. S. Kim, H. K. Byeon, S. Y. Lee and S. H. Kim (2013). Oncological and functional outcomes of transoral robotic surgery for oropharyngeal cancer. Br J Oral Maxillofac Surg 51(5): 408-412.

Weinstein, G. S., B. W. O’Malley, Jr., J. S. Magnuson, W. R. Carroll, K. D. Olsen, L. Daio, E. J. Moore and F. C. Holsinger (2012). Transoral robotic surgery: a multicenter study to assess feasibility, safety, and surgical margins. Laryngoscope 122(8): 1701-1707.

White, H., S. Ford, B. Bush, F. C. Holsinger, E. Moore, T. Ghanem, W. Carroll, E. Rosenthal, L. Sweeny and J. S. Magnuson (2013). Salvage surgery for recurrent cancers of the oropharynx: comparing TORS with standard open surgical approaches. JAMA Otolaryngol Head Neck Surg 139(8): 773-778.

White, H. N., E. J. Moore, E. L. Rosenthal, W. R. Carroll, K. D. Olsen, R. A. Desmond and J. S. Magnuson (2010). Transoral robotic-assisted surgery for head and neck squamous cell carcinoma: one- and 2-year survival analysis. Arch Otolaryngol Head Neck Surg 136(12): 1248-1252.

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