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William Spanos – Sioux Falls, South Dakota

Published on by William Spanos

Practice Contact Information

Sanford Health\Sanford Research, University of South Dakota Department of Surgery
1310 West 22nd Street, Sioux Falls, SD, USA

Sioux Falls
South Dakota
57105
United States

Phone: 605-328-8200
Email: [email protected]
Web Site: https://www.sanfordhealth.org/sioux-falls/services/head-neck-cancer/team

Areas of surgical specialization in Head and Neck Surgery

Endocrine Surgery, Head and Neck Research, Head and Neck Surgeon, Reconstructive Head & Neck Surgery

Biography/Statement

My academic and medical training background includes a strong track record of cancer focused research.  My laboratory focuses on the interaction between the immune system and the cancer cells in human papillomavirus driven head and neck cancers.  I also have an active medical practice caring for and treating head and neck cancer patients.  The failure of treatment in some patients and the morbidity associated with treatment motivate me to search for an improved molecular understanding of head and neck cancer through research.  Current treatment for recurrent metastatic head and neck cancer is limited in efficacy with significant side effects.  My recent research is focused on the interaction of the cancer cell, in the context of chemotherapy treatment, with the immune system and surrounding extracellular environment.  I hope to find ways to augment and modulate that interaction to improve response to treatment and to find less toxic therapy options.  Clinical research is also an important component of my role and I am principal investigator on several trials at Sanford Health.  My overall goal is to improve the treatment for head and neck cancer patients to limit morbidity and increase efficacy and I see research and clinical trials as the main way to make progress over the next five years.

Clinical Trials

Thyroid Cancer Collaborative Registry

Understanding Head and Neck Cancer Tissue Repository

Checkmate 358 (BMS)

Merck 689

NCCORP Sponsored Trials (ECOG 0232, RTOG 9507, HN003, HN004)

Bibliography

Landeen KC, Spanos WC, Gromer L. Topical superoxide dismutase in posttreatment fibrosis in patients with head and neck cancer. Head Neck. 2018 May 13. doi: 10.1002/hed.25119. [Epub ahead of print] PubMed PMID: 29756397.

Assam JH, Spanos WC. Oral Cavity Reconstruction Outcomes Using a Porcine Urinary Bladder Matrix: A Retrospective Case Series. Wounds. 2018 May;30(5):131-137. PubMed PMID: 29847304.

Assam JH, Spanos WC. Treatment of Peritonsillar Abscess in Immunosuppressed Patients. S D Med. 2017 Jul;70(7):314-316. PubMed PMID: 28806028.

Vermeer DW, Coppock JD, Zeng E, Lee KM, Spanos WC, Onken MD, Uppaluri R, Lee JH, Vermeer PD. Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis. Oncotarget. 2016 Apr 26;7(17):24194-207. doi: 10.18632/oncotarget.8254. PubMed PMID: 27013584; PubMed Central PMCID: PMC5029694.

Coppock JD, Vermeer PD, Vermeer DW, Lee KM, Miskimins WK, Spanos WC, Lee JH. mTOR inhibition as an adjuvant therapy in a metastatic model of HPV+ HNSCC. Oncotarget. 2016 Apr 26;7(17):24228-41. doi: 10.18632/oncotarget.8286. PubMed PMID: 27015118; PubMed Central PMCID: PMC5029697.
de la Garza G, Militsakh O, Panwar A, Galloway TL, Jorgensen JB, Ledgerwood LG, Kaiser K, Kitzerow C, Shnayder Y, Neumann CA, Khariwala SS, Chad Spanos W, Pagedar NA. Obesity and perioperative complications in head and neck free tissue reconstruction. Head Neck. 2016 Apr;38 Suppl 1:E1188-91. doi: 10.1002/hed.24189. Epub 2015 Aug 13. PubMed PMID: 26268587; PubMed Central PMCID: PMC4894301.
Assam JH, Powell S, Spanos WC. Unresectable cutaneous squamous cell carcinoma of the forehead with MLH1 mutation showing dramatic response to Programmed Cell Death Protein 1 Inhibitor Therapy. Clin Skin Cancer. 2016 Jan;1(1):26-29. doi: 10.1016/j.clsc.2016.11.001. Epub 2016 Nov 23. PubMed PMID: 29333502; PubMed Central PMCID: PMC5766284.
Terrell A, Gardner P, Spanos WC, Allard B, Barth R, Bhatia V, Lee J. Clinical Outcomes of a Team Approach to Thyroidectomy. S D Med. 2015 Dec;68(12):539-41. PubMed PMID: 26793931.
Smith RB, Evasovich M, Girod DA, Jorgensen JB, Lydiatt WM, Pagedar NA, Spanos WC. Ultrasound for localization in primary hyperparathyroidism. Otolaryngol Head Neck Surg. 2013 Sep;149(3):366-71. doi: 10.1177/0194599813491063. Epub 2013 Jun 7. PubMed PMID: 23748916.
Vermeer DW, Spanos WC, Vermeer PD, Bruns AM, Lee KM, Lee JH. Radiation-induced loss of cell surface CD47 enhances immune-mediated clearance of human papillomavirus-positive cancer. Int J Cancer. 2013 Jul;133(1):120-9. doi: 10.1002/ijc.28015. Epub 2013 Feb 12. PubMed PMID: 23292955; PubMed Central PMCID: PMC3972896.
Miller RA, Spanos WC, Jassim AD. Pathology quiz case 2. Folliculitis keloidalis nuchae. JAMA Otolaryngol Head Neck Surg. 2013 Apr;139(4):425-6. doi: 10.1001/jamaoto.2013.140a. PubMed PMID: 23599087.
Wieking BG, Vermeer DW, Spanos WC, Lee KM, Vermeer P, Lee WT, Xu Y, Gabitzsch ES, Balcaitis S, Balint JP Jr, Jones FR, Lee JH. A non-oncogenic HPV 16 E6/E7 vaccine enhances treatment of HPV expressing tumors. Cancer Gene Ther. 2012 Oct;19(10):667-74. doi: 10.1038/cgt.2012.55. Epub 2012 Aug 24. PubMed PMID: 22918471; PubMed Central PMCID: PMC3571619.
Spanos WC, Nowicki P, Lee DW, Hoover A, Hostager B, Gupta A, Anderson ME, Lee JH. Immune response during therapy with cisplatin or radiation for human papillomavirus-related head and neck cancer. Arch Otolaryngol Head Neck Surg. 2009 Nov;135(11):1137-46. doi: 10.1001/archoto.2009.159. PubMed PMID: 19917928.
Spanos WC, Brookes JT, Smith MC, Burkhart HM, Bell EF, Smith RJ. Unilateral vocal fold paralysis in premature infants after ligation of patent ductus arteriosus: vascular clip versus suture ligature. Ann Otol Rhinol Laryngol. 2009 Oct;118(10):750-3. PubMed PMID: 19894404.
Spanos WC, Hoover A, Harris GF, Wu S, Strand GL, Anderson ME, Klingelhutz AJ, Hendriks W, Bossler AD, Lee JH. The PDZ binding motif of human papillomavirus type 16 E6 induces PTPN13 loss, which allows anchorage-independent growth and synergizes with ras for invasive growth. J Virol. 2008 Mar;82(5):2493-500. Epub 2007 Dec 26. PubMed PMID: 18160445; PubMed Central PMCID: PMC2258903.
Spanos WC, Geiger J, Anderson ME, Harris GF, Bossler AD, Smith RB, Klingelhutz AJ, Lee JH. Deletion of the PDZ motif of HPV16 E6 preventing immortalization and anchorage-independent growth in human tonsil epithelial cells. Head Neck. 2008 Feb;30(2):139-47. PubMed PMID: 17657785; PubMed Central PMCID: PMC2600880.
Hoover AC, Spanos WC, Harris GF, Anderson ME, Klingelhutz AJ, Lee JH. The role of human papillomavirus 16 E6 in anchorage-independent and invasive growth of mouse tonsil epithelium. Arch Otolaryngol Head Neck Surg. 2007 May;133(5):495-502. PubMed PMID: 17515506; PubMed Central PMCID: PMC2917346.
Spanos WC, El-Deiry M, Lee JH. Cidofovir incorporation into human keratinocytes with episomal HPV 16 results in nonselective cytotoxicity. Ann Otol Rhinol Laryngol. 2005 Nov;114(11):840-6. PubMed PMID: 16363057.
Tuazon PT, Spanos WC, Gump EL, Monnig CA, Traugh JA. Determinants for substrate phosphorylation by p21-activated protein kinase (gamma-PAK). Biochemistry. 1997 Dec 23;36(51):16059-64. PubMed PMID: 9405039.

MICHAEL MCNICOLL – Los Angeles, California

Published on by Michael McNicoll

Practice Contact Information

Kaiser Permanente Medical Group
Head & Neck Surgical Oncology
4900 Sunset Boulevard
Los Angeles
California
90027
United States

Phone:
Email:
Web Site:

Areas of surgical specialization in Head and Neck Surgery

Endocrine Surgery, Head and Neck Surgeon

Biography/Statement

Member regional Head and Neck cancer multispecialty tumor board

Clinical Trials

Bibliography

Urjeet Patel – Chicago, Illinois

Published on by Urjeet Patel

Practice Contact Information

Northwestern University
676 North Saint Clair Street
#1325
Chicago
Illinois
60611
United States

Phone: 312-695-3222
Email: [email protected]
Web Site:

Areas of surgical specialization in Head and Neck Surgery

Head and Neck Research, Head and Neck Surgeon, Reconstructive Head & Neck Surgery

Biography/Statement

Dr. Patel was born and raised in Chicago and completed his undergraduate education at Brown University where he received his BA in Philosophy.  He attended Yale University for medical school and then completed residency in Otolaryngology—Head and Neck Surgery at Washington University in St. Louis.  He then joined Dr. Richard Hayden at the Mayo Clinic Scottsdale for a fellowship in Head and Neck Oncological and Microvascular Reconstructive Surgery.  He returned to Chicago in 2003 to join the staff at Stroger – Cook County Hospital where he now serves as Chairman of the Division of Otolaryngology and Chairman of the Cancer Committee.  He is recently promoted to full professor in the Department of Otolaryngology at Northwestern University.  He serves on several national committees for the American Head and Neck Society and currently serves as the Chairman of the Reconstructive Surgery Section.  He also participates in multi-institutional clinical trials for cancer treatment through the National Cancer Institute (NCI).  His clinical interests include head and neck oncologic surgery, minimally-invasive transoral robotic surgery (TORS), as well as reconstructive surgery with free tissue transfer.

Clinical Trials

Bibliography

Geoffrey Young – Miami, Florida

Published on by Geoffrey Young

Practice Contact Information

Chief of Head and Neck Surgery, Miami Cancer Institute
8900 N Kendall Dr.

Miami
Florida
33176
United States

Phone: 7865962000
Email: [email protected]
Web Site: https://baptisthealth.net/en/health-services/cancer-services/pages/cancer-care/adult-cancers/head-neck-cancers.aspx

Areas of surgical specialization in Head and Neck Surgery

Endocrine Surgery, Head and Neck Research, Head and Neck Surgeon

Biography/Statement

Dr. Young is an international leader in the field of head and neck surgical oncology.  He  specializes in minimally invasive, robotic and complex open surgery for both cancer and benign head and neck tumors.  He also an expert in the field of melanoma and other head and neck skin cancers. Dr. Young has authored numerous scientific articles and has been an invited speaker at national and international  meetings. His research interests include individualized medicine and surgical innovations for the management of head and neck  malignancies.

Clinical Trials

As part of the Memorial Sloane Kettering Alliance, Miami Cancer Institute has access to numerous clinical trials

Bibliography

Selected Bibliography
Peer-reviewed Articles
1. Young GD, Winokur TS, Cerfolio RJ, Van Tine BA, Chow LT, Okoh V, Garver RI Jr. Differential expression and biodistribution of cytokeratin 18 and desmoplakins in non-small cell lung carcinoma subtypes. Lung Cancer. 2002 May; 36(2):133-41. PMID:11955647

 
2. Okoh V, Young GD, Winokur TS, Garver RI Jr. A novel assay for the quantification of invasion from raft cultures of lung carcinomas. Clin Exp Metastasis. 2004; 21(1):1-6. PMID:15065596

 
3. Rosenthal E, McCrory A, Talbert M, Young G, Murphy-Ullrich J, Gladson C. Elevated expression of TGF-beta1 in head and neck cancer-associated fibroblasts. Mol Carcinog. 2004 Jun; 40(2):116-21. PMID:15170816   DOI:10.1002/mc.20024

 
4. Young GD, Murphy-Ullrich JE. Molecular interactions that confer latency to transforming growth factor-beta. J Biol Chem. 2004 Sep 3; 279(36):38032-9. Epub 2004 Jun 18. PMID:15208302   DOI:10.1074/jbc.M405658200

 
5. Young GD, Murphy-Ullrich JE. The tryptophan-rich motifs of the thrombospondin type 1 repeats bind VLAL motifs in the latent transforming growth factor-beta complex. J Biol Chem. 2004 Nov 12; 279(46):47633-42. Epub 2004 Sep 01. PMID:15342643   DOI:10.1074/jbc.M404918200

 
6. Taube JM, Anders RA, Young GD, Xu H, Sharma R, McMiller TL, Chen S, Klein AP, Pardoll DM, Topalian SL, Chen L. Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci Transl Med. 2012 Mar 28; 4(127):127ra37. PMID:22461641   PMCID:3568523   DOI:10.1126/scitranslmed.3003689

 
7. Lyford-Pike S, Peng S, Young GD, Taube JM, Westra WH, Akpeng B, Bruno TC, Richmon JD, Wang H, Bishop JA, Chen L, Drake CG, Topalian SL, Pardoll DM, Pai SI. Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma. Cancer Res. 2013 Mar 15; 73(6):1733-41. Epub 2013 Jan 03. PMID:23288508   PMCID:3602406   DOI:10.1158/0008-5472.CAN-12-2384

 
8. Taube JM, Young GD, McMiller TL, Chen S, Salas JT, Pritchard TS, Xu H, Meeker AK, Fan J, Cheadle C, Berger AE, Pardoll DM, Topalian SL. Differential expression of immune-regulatory genes associated with PD-L1 display in melanoma: Implications for PD-1 pathway blockade. Clin Cancer Res. 2015; 21(17):3969-76. PMID:25944800

 
9. Gamez ME, Jeans E, Hinni ML, Moore E, Young G, Ma D, McGee L, Buras MR, Patel SH. Outcomes and patterns of failure of sarcomatoid carcinoma of the larynx: The Mayo Clinic experience. Laryngoscope 2017 Jul 06 Epub 2017 July 06 PMID:28681992   DOI:10.1002/lary.26725

 

Steven Sperry – Milwaukee, WI

Published on by Steven Sperry

Practice Contact Information

Aurora St. Luke’s Medical Center
2801 W. Kinnickinnic River Pkwy
Suite 525
Milwaukee
WI
53215
United States

Phone: 414-281-4466
Email:
Web Site:

Areas of surgical specialization in Head and Neck Surgery

Endocrine Surgery, Head and Neck Surgeon, Reconstructive Head & Neck Surgery

Biography/Statement

Dr. Sperry is a fellowship-trained Head and Neck and Reconstructive Surgeon in Milwaukee, Wisconsin. He completed residency at the University of Pennsylvania and fellowship at the University of Iowa, and was a clinical professor on the faculty at the University of Iowa prior to relocating to Milwaukee. He sees patients with tumors of the head and neck and thyroid gland, and also specializes in complex reconstructive procedures, utilizing microvascular free tissue transfer techniques.

Clinical Trials

Bibliography

Independent Predictors of Prognosis Based on Oral Cavity Squamous Cell Carcinoma Surgical Margins.

Buchakjian MR, Ginader T, Tasche KK, Pagedar NA, Smith BJ, Sperry SM.

Otolaryngol Head Neck Surg. 2018 May 1:194599818773070. doi: 10.1177/0194599818773070.

 

A Hairy Situation: Laser Hair Removal after Oral Reconstruction.

Shields BE, Moye MS, Bayon R, Sperry SM, Wanat KA.

Ann Otol Rhinol Laryngol. 2018 Mar;127(3):205-208. doi: 10.1177/0003489417750930.

 

Longitudinal Perioperative Pain Assessment in Head and Neck Cancer Surgery.

Buchakjian MR, Davis AB, Sciegienka SJ, Pagedar NA, Sperry SM.

Ann Otol Rhinol Laryngol. 2017 Sep;126(9):646-653. doi: 10.1177/0003489417723034..

 

Definition of “Close Margin” in Oral Cancer Surgery and Association of Margin Distance With Local Recurrence Rate.

Tasche KK, Buchakjian MR, Pagedar NA, Sperry SM.

JAMA Otolaryngol Head Neck Surg. 2017 Dec 1;143(12):1166-1172. doi: 10.1001/jamaoto.2017.0548.

 

Survival outcomes in elderly patients with untreated upper aerodigestive tract cancer.

Hughley BB, Sperry SM, Thomsen TA, Charlton ME, Pagedar NA.

Head Neck. 2017 Feb;39(2):215-218. doi: 10.1002/hed.24565.

 

Association of Main Specimen and Tumor Bed Margin Status With Local Recurrence and Survival in Oral Cancer Surgery.

Buchakjian MR, Tasche KK, Robinson RA, Pagedar NA, Sperry SM.

JAMA Otolaryngol Head Neck Surg. 2016 Dec 1;142(12):1191-1198. doi: 10.1001/jamaoto.2016.2329.

 

Correlating thyroid cytology and histopathology: Implications for molecular testing.

Reed MJ, Sperry SM, Gailey MP, Jensen CS, Robinson RA, Funk GF, Pagedar NA.

Head Neck. 2016 Jul;38(7):1104-6. doi: 10.1002/hed.24410.

 

The University of Pennsylvania curriculum for training otorhinolaryngology residents in transoral robotic surgery.

Sperry SM, O’Malley BW Jr, Weinstein GS.

ORL J Otorhinolaryngol Relat Spec. 2014;76(6):342-52. doi: 10.1159/000369624.

 

Influence of body composition on survival in patients with head and neck cancer.

Karnell LH, Sperry SM, Anderson CM, Pagedar NA.

Head Neck. 2016 Apr;38 Suppl 1:E261-7. doi: 10.1002/hed.23983.

 

Association of sentinel lymph node biopsy with survival for head and neck melanoma: survival analysis using the SEER database.

Sperry SM, Charlton ME, Pagedar NA.

JAMA Otolaryngol Head Neck Surg. 2014 Dec;140(12):1101-9. doi: 10.1001/jamaoto.2014.2530.

 

Comparison between Organ Preservation Surgery and Radiation in Early Supraglottic Carcinoma Is Limited by Bias.

Sperry SM, Pagedar NA.

Otolaryngol Head Neck Surg. 2014 Jul;151(1):182. doi: 10.1177/0194599814536362.

 

Supracricoid partial laryngectomy for primary and recurrent laryngeal cancer.

Sperry SM, Rassekh CH, Laccourreye O, Weinstein GS.

JAMA Otolaryngol Head Neck Surg. 2013 Nov;139(11):1226-35. doi: 10.1001/jamaoto.2013.4990.

 

EGFR inhibition promotes an aggressive invasion pattern mediated by mesenchymal-like tumor cells within squamous cell carcinomas.

Basu D, Bewley AF, Sperry SM, Montone KT, Gimotty PA, Rasanen K, Facompre ND, Weinstein GS, Nakagawa H, Diehl JA, Rustgi AK, Herlyn M.

Mol Cancer Ther. 2013 Oct;12(10):2176-86. doi: 10.1158/1535-7163.MCT-12-1210.