4MOSC1, 4MOSC2
Investigator NameSilvio Gutkind
Investigator InstitutionUC San Diego, Moores Cancer Center
Lab Contact NameFarhoud Faraji
Lab Contact EmailEmail hidden; Javascript is required.
Lab Contact Phone(916) 508-9300
Histology
Differentiated squamous cell carcinoma
Species
Mus musculus domesticus, C57BL/6NCrl
Site of Origin
Oral tongue
Genomic Characteristics
Carcinoma induced via 4-NQO mediated chemical carcinogenesis. For detailed genomic characterization, see source article:
https://www.nature.com/articles/s41467-019-13471-0
In brief:
4MOSC1 - Trp53, Fat1, Notch2 mutant
4MOSC2 - Trp53, Keap1, Nf1, Ctnnb1, Kmt2b mutant
HPV Status
Negative
Established?
Yes
Primary non-immortalized
No
Fluorescence or other transgene status
None, but available with stably transduced GFP-ffLuc (via Addgene #46793 lenti)
Engraftment sites in vivo
Orthotopic
Media Composition
Keratinocyte serum free media with defined growth supplement mix, murine EGF, and cholera toxin
MTA Required
No
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